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- W2983661566 abstract "Abstract In mice, the ability of naive T (TN) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8+ TN cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3+ TN cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide–HLA class I Ags. Moreover, CXCR3+ TN cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3+ TN cells were transcriptionally equivalent to murine CXCR3+ TN cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8+ T cells." @default.
- W2983661566 created "2019-11-22" @default.
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- W2983661566 date "2019-12-15" @default.
- W2983661566 modified "2023-10-18" @default.
- W2983661566 title "CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential" @default.
- W2983661566 cites W1500954694 @default.
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- W2983661566 cites W1600928734 @default.
- W2983661566 cites W1601910169 @default.
- W2983661566 cites W1971806373 @default.
- W2983661566 cites W1973639800 @default.
- W2983661566 cites W1974424684 @default.
- W2983661566 cites W1974842026 @default.
- W2983661566 cites W1981542309 @default.
- W2983661566 cites W1992267675 @default.
- W2983661566 cites W1994500716 @default.
- W2983661566 cites W2005251753 @default.
- W2983661566 cites W2006192795 @default.
- W2983661566 cites W2008366157 @default.
- W2983661566 cites W2016836061 @default.
- W2983661566 cites W2018311892 @default.
- W2983661566 cites W2021945571 @default.
- W2983661566 cites W2051241958 @default.
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- W2983661566 cites W2073655356 @default.
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- W2983661566 cites W2086221877 @default.
- W2983661566 cites W2086418273 @default.
- W2983661566 cites W2086608172 @default.
- W2983661566 cites W2089041106 @default.
- W2983661566 cites W2090342830 @default.
- W2983661566 cites W2091134572 @default.
- W2983661566 cites W2094736478 @default.
- W2983661566 cites W2098380237 @default.
- W2983661566 cites W2099295104 @default.
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- W2983661566 cites W2113847305 @default.
- W2983661566 cites W2114104545 @default.
- W2983661566 cites W2127436026 @default.
- W2983661566 cites W2135511012 @default.
- W2983661566 cites W2135987669 @default.
- W2983661566 cites W2144796561 @default.
- W2983661566 cites W2146512944 @default.
- W2983661566 cites W2150178690 @default.
- W2983661566 cites W2155059804 @default.
- W2983661566 cites W2157384708 @default.
- W2983661566 cites W2161195685 @default.
- W2983661566 cites W2165348349 @default.
- W2983661566 cites W2165647354 @default.
- W2983661566 cites W2165918521 @default.
- W2983661566 cites W2167008563 @default.
- W2983661566 cites W2168562934 @default.
- W2983661566 cites W2169456326 @default.
- W2983661566 cites W2170989872 @default.
- W2983661566 cites W2171546617 @default.
- W2983661566 cites W2174247606 @default.
- W2983661566 cites W2185265351 @default.
- W2983661566 cites W2245303435 @default.
- W2983661566 cites W2368915317 @default.
- W2983661566 cites W2412807878 @default.
- W2983661566 cites W2413290837 @default.
- W2983661566 cites W2467278060 @default.
- W2983661566 cites W2517078013 @default.
- W2983661566 cites W2760375764 @default.
- W2983661566 cites W2761516325 @default.
- W2983661566 cites W2763557630 @default.