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- W2983670537 abstract "The research on the synergy caused by the dual abuse of opioids and ethanol has been one of the highly attractive topics in the fields of chemistry, pharmacy and forensic science. Based on spectral analysis and in vivo experiments in rats, this article systematically explored the synergistic mechanism. The results show that different concentrations of ethanol in the blood can reduce binding equilibrium constants of morphine-HSA and heroin-HSA complexes to varying degrees in the early stages of morphine and heroin metabolism. The concentration of free morphine and heroin in the blood is rapidly increased in a short time, the metabolic process is obviously slowed down, and the high concentration level can be maintained in the blood for a long time, thereby enhancing the efficacy of morphine and heroin in the body and the subjective feelings as well producing a synergistic effect. At the same time, the concentration of the more active morphine metabolic intermediate M-6-G in the blood shows a tendency to increase slowly, further strengthening the synergy between morphine and ethanol." @default.
- W2983670537 created "2019-11-22" @default.
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- W2983670537 date "2019-10-01" @default.
- W2983670537 modified "2023-10-16" @default.
- W2983670537 title "Molecular spectroscopic studies examining the synergistic mechanism of opioid morphine, heroin and ethanol" @default.
- W2983670537 doi "https://doi.org/10.1360/ssc-2019-0095" @default.
- W2983670537 hasPublicationYear "2019" @default.
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