Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983702404> ?p ?o ?g. }
- W2983702404 endingPage "107808" @default.
- W2983702404 startingPage "107808" @default.
- W2983702404 abstract "Medications that improve pain threshold can be useful in the pharmacotherapy of Parkinson's disease (PD). Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients. However, specific therapy for PD-related pain are not available. Since the endocannabinoid system is expressed extensively in different levels of pain pathway, drugs designed to target this system have promising therapeutic potential in the modulation of pain. Thus, we examined the effects of the 6-hydroxydopamine- induced PD on nociceptive responses of mice and the influence of cannabidiol (CBD) on 6-hydroxydopamine-induced nociception. Further, we investigated the pathway involved in the analgesic effect of the CBD through the co-administration with a fatty acid amide hydrolase (FAAH) inhibitor, increasing the endogenous anandamide levels, and possible targets from anandamide, i.e., the cannabinoid receptors subtype 1 and 2 (CB1 and CB2) and the transient receptor potential vanilloid type 1 (TRPV1). We report that 6-hydroxydopamine- induced parkinsonism decreases the thermal and mechanical nociceptive threshold, whereas CBD (acute and chronic treatment) reduces this hyperalgesia and allodynia evoked by 6-hydroxydopamine. Moreover, ineffective doses of either FAAH inhibitor or TRPV1 receptor antagonist potentialized the CBD-evoked antinociception while an inverse agonist of the CB1 and CB2 receptor prevented the antinociceptive effect of the CBD. Altogether, these results indicate that CBD can be a useful drug to prevent the parkinsonism-induced nociceptive threshold reduction. They also suggest that CB1 and TRPV1 receptors are important for CBD-induced analgesia and that CBD could produce these analgesic effects increasing endogenous anandamide levels." @default.
- W2983702404 created "2019-11-22" @default.
- W2983702404 creator A5058094517 @default.
- W2983702404 creator A5058457121 @default.
- W2983702404 creator A5070819494 @default.
- W2983702404 creator A5081180227 @default.
- W2983702404 creator A5081635329 @default.
- W2983702404 creator A5087700138 @default.
- W2983702404 date "2020-02-01" @default.
- W2983702404 modified "2023-10-14" @default.
- W2983702404 title "Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease" @default.
- W2983702404 cites W1235781926 @default.
- W2983702404 cites W1488425174 @default.
- W2983702404 cites W1571837352 @default.
- W2983702404 cites W1959296941 @default.
- W2983702404 cites W1964600015 @default.
- W2983702404 cites W1969613508 @default.
- W2983702404 cites W1969953780 @default.
- W2983702404 cites W1971135806 @default.
- W2983702404 cites W1971339908 @default.
- W2983702404 cites W1999460576 @default.
- W2983702404 cites W2002289659 @default.
- W2983702404 cites W2009845708 @default.
- W2983702404 cites W2009864778 @default.
- W2983702404 cites W2012407109 @default.
- W2983702404 cites W2023366312 @default.
- W2983702404 cites W2049573982 @default.
- W2983702404 cites W2057468498 @default.
- W2983702404 cites W2057487813 @default.
- W2983702404 cites W2061771087 @default.
- W2983702404 cites W2066159223 @default.
- W2983702404 cites W2069414159 @default.
- W2983702404 cites W2071334120 @default.
- W2983702404 cites W2076719478 @default.
- W2983702404 cites W2078308586 @default.
- W2983702404 cites W2082215577 @default.
- W2983702404 cites W2088493438 @default.
- W2983702404 cites W2101643484 @default.
- W2983702404 cites W2116439316 @default.
- W2983702404 cites W2122384242 @default.
- W2983702404 cites W2130435998 @default.
- W2983702404 cites W2131100809 @default.
- W2983702404 cites W2132380973 @default.
- W2983702404 cites W2132967603 @default.
- W2983702404 cites W2133728467 @default.
- W2983702404 cites W2136557533 @default.
- W2983702404 cites W2141879260 @default.
- W2983702404 cites W2141929843 @default.
- W2983702404 cites W2142460361 @default.
- W2983702404 cites W2147551595 @default.
- W2983702404 cites W2160094781 @default.
- W2983702404 cites W2160569512 @default.
- W2983702404 cites W2161722441 @default.
- W2983702404 cites W2161724754 @default.
- W2983702404 cites W2162816987 @default.
- W2983702404 cites W2166211493 @default.
- W2983702404 cites W2168111104 @default.
- W2983702404 cites W2169269177 @default.
- W2983702404 cites W2172201406 @default.
- W2983702404 cites W2230505097 @default.
- W2983702404 cites W2283995152 @default.
- W2983702404 cites W2370958077 @default.
- W2983702404 cites W2460083407 @default.
- W2983702404 cites W2472577276 @default.
- W2983702404 cites W2520865586 @default.
- W2983702404 cites W2539941811 @default.
- W2983702404 cites W2589113639 @default.
- W2983702404 cites W2611371989 @default.
- W2983702404 cites W2612695280 @default.
- W2983702404 cites W2617094927 @default.
- W2983702404 cites W2674847416 @default.
- W2983702404 cites W2734940003 @default.
- W2983702404 cites W2753371907 @default.
- W2983702404 cites W2762038223 @default.
- W2983702404 cites W2785556833 @default.
- W2983702404 cites W2795903299 @default.
- W2983702404 cites W2800909437 @default.
- W2983702404 cites W2800913246 @default.
- W2983702404 cites W2803143946 @default.
- W2983702404 cites W2890537675 @default.
- W2983702404 cites W2895936070 @default.
- W2983702404 cites W2903164652 @default.
- W2983702404 cites W2908548900 @default.
- W2983702404 cites W2914777103 @default.
- W2983702404 cites W2919893877 @default.
- W2983702404 cites W62603772 @default.
- W2983702404 doi "https://doi.org/10.1016/j.neuropharm.2019.107808" @default.
- W2983702404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31706993" @default.
- W2983702404 hasPublicationYear "2020" @default.
- W2983702404 type Work @default.
- W2983702404 sameAs 2983702404 @default.
- W2983702404 citedByCount "30" @default.
- W2983702404 countsByYear W29837024042020 @default.
- W2983702404 countsByYear W29837024042021 @default.
- W2983702404 countsByYear W29837024042022 @default.
- W2983702404 countsByYear W29837024042023 @default.
- W2983702404 crossrefType "journal-article" @default.
- W2983702404 hasAuthorship W2983702404A5058094517 @default.