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- W2983735656 abstract "Aim: Hypertension is a major health problem worldwide resulting in high death rates due to its consequences and complications. Therefore, searching for new vasorelaxants is a must to find new vasodilators efficient for the treatment of different cardiovascular diseases. Methodology: Different 6-phenyl-3-pyridazinone based derivatives were synthesized and screened for their vasorelaxant activity according to the reported method using hydralazine as a standard. Results: The tested compounds revealed potent to mild activity with EC 50 values 0.339–114.300 μM compared with hydralazine EC 50 = 18.210 μM. Conclusion: The most active compounds were the acid 5, its ester analog 4 and 4-methoxyphenylhydrazide derivative 10c (EC 50 = 0.339, 1.225 and 1.204 μM, respectively). Therefore, 6-phenylpyridazin-3(2 H)-one can be a hit for structural optimization to obtain promising vasorelaxants." @default.
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- W2983735656 date "2020-01-01" @default.
- W2983735656 modified "2023-09-27" @default.
- W2983735656 title "Synthesis and vasodilator activity of some pyridazin-3(2<i>H</i>)-one based compounds" @default.
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- W2983735656 doi "https://doi.org/10.4155/fmc-2019-0160" @default.
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