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- W2983755767 abstract "Objective: To investigate the significance of the detection of pepsin in saliva and the pharyngeal pH monitoring in the diagnosis of laryngopharyngeal reflux disease(LPRD). Methods: A total of 176 patients (140 patients with simple pharyngitis and 36 patients with space-occupying lesions of larynx) who were suspected to have laryngopharyngeal reflux between February and December 2016 were retrospectively reviewed. All the patients were evaluated with reflux symptom index (RSI), reflux finding score (RFS) and 24-hour pharyngeal pH monitoring(Dx-pH). Saliva of patients was collected and the pepsin in the saliva was measured by enzyme-linked immunosorbent assay (ELISA). Results: The positive rate of RSI (RSI>13) and/or RFS (RFS>7) was 56.8% (100/176). The positive rate of pepsin in saliva was 40.9% (72/176) and pepsin in saliva collected at the time of onset of symptom was much higher than that at other time points (P<0.001). The positive rate of pepsin in saliva, Ryan score and the pH<6.0 laryngopharyngeal reflux in space-occupying lesions group [55.6%(20/36), 27.8% (10/36), 69.4%(25/36), respectively] were all higher than simple pharyngitis group [37.1% (52/140), 5.0% (7/140), 50% (70/140), respectively] (P=0.045, P<0.001, P=0.037, respectively). Conclusions: The detection of pepsin in saliva and the pharyngeal pH monitoring reflected different reflux agents, and there was great significance for the diagnosis of LPRD by using two methods together. We found that the weak acid state and consequent pepsin damage played an important role in the occurrence and development of space-occupying lesions of larynx.目的：探讨唾液胃蛋白酶检测及咽部pH检测方法对咽喉反流性疾病(LPRD)的诊断意义。 方法：回顾性分析2016年2至12月解放军第三〇六医院耳鼻咽喉头颈外科疑有咽喉反流的176例患者(单纯咽喉炎患者140例，咽喉占位性病变患者36例)咽部pH(Dx－pH)检测结果及唾液胃蛋白酶酶联免疫吸附检测结果，所有患者均填写反流症状指数(RSI)量表并行反流体征评分(RFS)。 结果： 176例患者量表评分阳性率为56.8%(100/176)，唾液胃蛋白酶检测阳性率40.9%(72/176)。症状发作时唾液胃蛋白酶阳性率明显高于其他时间点(P<0.001)。咽喉占位性病变患者唾液胃蛋白酶阳性率(55.6%，20/36)高于单纯咽喉炎组(37.1%，52/140)(P＝0.045)。咽喉占位性病变患者咽部pH检测Ryan指数阳性率[27.8%(10/36)比5.0%(7/140)，P<0.001]及pH<6.0反流阳性率[69.4%(25/36)比50%(70/140)，P＝0.037]均高于单纯咽喉炎患者。 结论：咽部pH检测及唾液胃蛋白酶检测分别反映咽喉反流的不同物质，两者联合使用对LPRD诊断价值更大。弱酸状态及由此引发的胃蛋白酶对黏膜的损伤对咽喉占位性病变的发生发展起到一定作用。." @default.
- W2983755767 created "2019-11-22" @default.
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- W2983755767 date "2018-02-27" @default.
- W2983755767 modified "2023-09-27" @default.
- W2983755767 title "[Significance of pharyngeal biochemical indexes in the diagnosis of laryngopharyngeal reflux disease]." @default.
- W2983755767 doi "https://doi.org/10.3760/cma.j.issn.0376-2491.2018.08.009" @default.
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