FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2983897056> ?p ?o ?g. }

• W2983897056 endingPage "151854" @default.
• W2983897056 startingPage "151854" @default.
• W2983897056 abstract "Dendritic cells (DCs) are immune cells that surveil the organism for infections or malignancies and activate specific T lymphocytes initiating specific immune responses. Contrariwise, DCs have been show to participate in the development of diseases, among them some types of cancer by inducing angiogenesis or immunosuppression. The ultimate fate of DC functions regarding their role in disease or health is prompted by signals from the microenvironment. We have previously shown that the interaction of DCs with various extracellular matrix components modifies the immune properties and angiogenic potential of these cells. The objective of the current studies was to investigate the angiogenic and immune profile of murine myeloid DCs upon interaction with laminin environments, with a particular emphasis on ovarian cancer. Our results show that murine ovarian tumors produce several types of laminins, as determined by PCR analysis, and also that tumor-associated DCs, both from ascites or solid tumors express adhesion molecules capable of interacting with these molecules as determined by flow cytometry and PCR analysis. Further, we established that DCs cultured on laminin upregulate both AKT and MEK signaling pathways, and that long-term culture on laminin surfaces decreases the immunological capacities of these cells when compared to the same cells cultured on synthetic substrates. In addition, we observed that tumor conditioned media was able to modify the metabolic status of these cells, and also reprogram the development of DCs from bone marrow precursors towards the generation of myeloid-derived suppressor cells. Overall, these studies demonstrate that the interaction between soluble factors and extracellular matrix components of the ovarian cancer microenvironment shape the biology of DCs and thus help them become co-conspirators of tumor growth." @default.
• W2983897056 created "2019-11-22" @default.
• W2983897056 creator A5001865590 @default.
• W2983897056 creator A5006679650 @default.
• W2983897056 creator A5014611182 @default.
• W2983897056 creator A5020876678 @default.
• W2983897056 creator A5047180663 @default.
• W2983897056 creator A5068732766 @default.
• W2983897056 creator A5075832130 @default.
• W2983897056 creator A5085868066 @default.
• W2983897056 date "2020-01-01" @default.
• W2983897056 modified "2023-10-06" @default.
• W2983897056 title "Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells" @default.
• W2983897056 cites W1497241398 @default.
• W2983897056 cites W1585647397 @default.
• W2983897056 cites W1669937501 @default.
• W2983897056 cites W1678477267 @default.
• W2983897056 cites W1689372518 @default.
• W2983897056 cites W1761790947 @default.
• W2983897056 cites W1906377272 @default.
• W2983897056 cites W1955252259 @default.
• W2983897056 cites W1981400650 @default.
• W2983897056 cites W1984422348 @default.
• W2983897056 cites W1986063172 @default.
• W2983897056 cites W1990083653 @default.
• W2983897056 cites W1990235635 @default.
• W2983897056 cites W1992439632 @default.
• W2983897056 cites W2009948752 @default.
• W2983897056 cites W2017525816 @default.
• W2983897056 cites W2019541940 @default.
• W2983897056 cites W2019651445 @default.
• W2983897056 cites W2020203977 @default.
• W2983897056 cites W2020501054 @default.
• W2983897056 cites W2022655834 @default.
• W2983897056 cites W2023818726 @default.
• W2983897056 cites W2031866250 @default.
• W2983897056 cites W2037707039 @default.
• W2983897056 cites W2038436501 @default.
• W2983897056 cites W2041245511 @default.
• W2983897056 cites W2045121415 @default.
• W2983897056 cites W2054581136 @default.
• W2983897056 cites W2062843702 @default.
• W2983897056 cites W2076936113 @default.
• W2983897056 cites W2083914055 @default.
• W2983897056 cites W2084006363 @default.
• W2983897056 cites W2087752435 @default.
• W2983897056 cites W2088402590 @default.
• W2983897056 cites W2088571368 @default.
• W2983897056 cites W2092235636 @default.
• W2983897056 cites W2094616018 @default.
• W2983897056 cites W2101018118 @default.
• W2983897056 cites W2108086513 @default.
• W2983897056 cites W2108144981 @default.
• W2983897056 cites W2110722277 @default.
• W2983897056 cites W2111220263 @default.
• W2983897056 cites W2114195790 @default.
• W2983897056 cites W2125533152 @default.
• W2983897056 cites W2126593444 @default.
• W2983897056 cites W2128818080 @default.
• W2983897056 cites W2133062667 @default.
• W2983897056 cites W2133324199 @default.
• W2983897056 cites W2134905361 @default.
• W2983897056 cites W2139868023 @default.
• W2983897056 cites W2142858201 @default.
• W2983897056 cites W2144144301 @default.
• W2983897056 cites W2150473997 @default.
• W2983897056 cites W2150780552 @default.
• W2983897056 cites W2167733085 @default.
• W2983897056 cites W2171249989 @default.
• W2983897056 cites W2297773450 @default.
• W2983897056 cites W2371832373 @default.
• W2983897056 cites W2397941389 @default.
• W2983897056 cites W2586195606 @default.
• W2983897056 cites W2619078406 @default.
• W2983897056 cites W2628676876 @default.
• W2983897056 cites W2730731865 @default.
• W2983897056 cites W2735904407 @default.
• W2983897056 cites W2741013871 @default.
• W2983897056 cites W2769142715 @default.
• W2983897056 cites W2796271069 @default.
• W2983897056 cites W2810896552 @default.
• W2983897056 doi "https://doi.org/10.1016/j.imbio.2019.10.003" @default.
• W2983897056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31753553" @default.
• W2983897056 hasPublicationYear "2020" @default.
• W2983897056 type Work @default.
• W2983897056 sameAs 2983897056 @default.
• W2983897056 citedByCount "5" @default.
• W2983897056 countsByYear W29838970562021 @default.
• W2983897056 countsByYear W29838970562022 @default.
• W2983897056 countsByYear W29838970562023 @default.
• W2983897056 crossrefType "journal-article" @default.
• W2983897056 hasAuthorship W2983897056A5001865590 @default.
• W2983897056 hasAuthorship W2983897056A5006679650 @default.
• W2983897056 hasAuthorship W2983897056A5014611182 @default.
• W2983897056 hasAuthorship W2983897056A5020876678 @default.
• W2983897056 hasAuthorship W2983897056A5047180663 @default.
• W2983897056 hasAuthorship W2983897056A5068732766 @default.
• W2983897056 hasAuthorship W2983897056A5075832130 @default.

• next