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- W2983997908 abstract "Introduction/Background Vulvar sarcomas are rare low genital tract malignancies accounting less then 1–3% of all vulvar cancers. The purpose of the study was to assess clinical and morphological features of vulvar sarcomas. Methodology All the cases of Vulvar sarcomas treated in the National Medical Research Center of Oncology named after N.N.Petrov were detected during the period 2007–2017. Results Through the 10-year period 6 cases of vulvar sarcomas were detected from 251 cases of vulvar malignancies. Five cases were presented by leiomyosarcomas, one case by Dermatofibrosarcoma protuberans. The age of patients with leiomyosarcomas varied over a wide range, 28–85 years, averaging 55 years. The patient with Dermatfibrosarcoma was 63 years old. Four patients with leyomiosarcomas had Stage I disease (the size of the tumor less then 5 cm) only one patient had II stage of disease. No presence of regional node spread was detected. All the patients were surgically treated (vulvectomy/hemivulvectomy), one patient received radiotherapy. Patient with Dermatofibrosarcoma protuberans stage I was CD34 positive, while EMA, SMA, MSA, Desmin - negative, with Ki67-2%. After surgical treatment in 2014 she is alive without signs of disease. All the patients with Ist stage of leiomyosarcomas were alive through the 5-year period of follow-up. Three of them had no signs of disease through this period of follow-up. One patient had local recurrence surgically treated. One patient with stage II disease experienced repeated local recurrences after initial surgical treatment with secondary surgical treatment. Distant pulmonary recurrence occurred after 21 months after initial treatment successfully treated by local resection and chemotherapy. The patient is stable after 49 months of follow-up after initial treatment. Conclusion Vulvar sarcomas are rare malignancies with favourable prognosis in case of timely diagnosis with main management option - surgical treatment. Disclosure Nothing to disclose." @default.
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- W2983997908 date "2019-11-01" @default.
- W2983997908 modified "2023-10-18" @default.
- W2983997908 title "EP760 Vulvar sarcoma – rare malignancy with favorable prognosis in case of timely diagnosis and treatment" @default.
- W2983997908 doi "https://doi.org/10.1136/ijgc-2019-esgo.811" @default.
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