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• W2984084259 abstract "Summary Objectives To determine whether it was feasible to use a haemorrhage assessment tool (HAT) within a trauma trial and whether the data obtained could differentiate patients who had achieved haemostasis. Background Major haemorrhage is one of the leading causes of death worldwide, affecting 40% of trauma patients. Clinical trials evaluating haemostatic interventions often use transfusion outcomes as a primary endpoint. Transfusion is highly dependent on local practice, limiting its reliability as a robust, transferable endpoint. Methods A five‐point HAT questionnaire was applied to participants enrolled into the EFIT‐1 trial. This RCT evaluated the feasibility of administering a 6 g fibrinogen concentrate to patients with severe trauma haemorrhage. Results Of participants, 98% completed a HAT; 75% participants had ‘achieved haemostasis’ at the time of tool completion, as determined by clinical acumen alone. HAT scores were able to differentiate which participants required transfusion after 3 h. Of participants, 56% were transfused red blood cells when they scored 0–2, compared to 17% with HAT scores between 3 and 5. Conclusion This study has confirmed the feasibility of using a HAT during the emergency care of patients suffering trauma haemorrhage, and future studies should be conducted to determine its value as an endpoint in haemostasis studies." @default.
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• W2984084259 date "2019-11-03" @default.
• W2984084259 modified "2023-10-18" @default.
• W2984084259 title "The application of a haemorrhage assessment tool in evaluating control of bleeding in a pilot trauma haemorrhage trial" @default.
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• W2984084259 doi "https://doi.org/10.1111/tme.12644" @default.
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