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• W2984136935 abstract "The immunostimulator Victrio consists of bacterial plasmid DNA encased in cationic liposomes and protects embryonated chicken eggs and newly hatched chickens against Escherichia coli induced mortality. It is demonstrated that Victrio specifically and potently activates recombinant chicken toll-like receptor 21 (TLR21) in a nuclear factor kappa B reporter gene assay. This TLR21 stimulatory activity is dependent on the presence of nonmethylated CpG and requires liposomal formulation of the DNA, as naked plasmid DNA proves to be inactive. Nitric oxide production is induced by Victrio in HD11 chicken macrophages that express TLR21 naturally, supporting the proposal that chicken TLR21 is a component of the molecular mode of action of Victrio." @default.
• W2984136935 created "2019-11-22" @default.
• W2984136935 creator A5052177965 @default.
• W2984136935 date "2020-02-01" @default.
• W2984136935 modified "2023-09-24" @default.
• W2984136935 title "The immunostimulator Victrio activates chicken toll-like receptor 21" @default.
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• W2984136935 doi "https://doi.org/10.1016/j.vetimm.2019.109977" @default.
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