Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984202313> ?p ?o ?g. }
- W2984202313 abstract "ABSTRACT Neutrophils are primary phagocytes of the innate immune system that generate reactive oxygen species (ROS) and mediate host defense. Deficient phagocyte NADPH oxidase (PHOX) function leads to chronic granulomatous disease (CGD) that is characterized by invasive infections, including those by the generally non-pathogenic fungus Aspergillus nidulans. The role of neutrophil ROS in this specific host–pathogen interaction remains unclear. Here, we exploit the optical transparency of zebrafish to image the effects of neutrophil ROS on invasive fungal growth and neutrophil behavior in response to Aspergillus nidulans. In a wild-type host, A. nidulans germinates rapidly and elicits a robust inflammatory response with efficient fungal clearance. PHOX-deficient larvae have increased susceptibility to invasive A. nidulans infection despite robust neutrophil infiltration. Expression of subunit p22phox (officially known as CYBA), specifically in neutrophils, does not affect fungal germination but instead limits the area of fungal growth and excessive neutrophil inflammation and is sufficient to restore host survival in p22phox-deficient larvae. These findings suggest that neutrophil ROS limits invasive fungal growth and has immunomodulatory activities that contribute to the specific susceptibility of PHOX-deficient hosts to invasive A. nidulans infection." @default.
- W2984202313 created "2019-11-22" @default.
- W2984202313 creator A5011009871 @default.
- W2984202313 creator A5019614963 @default.
- W2984202313 creator A5026436548 @default.
- W2984202313 creator A5037833836 @default.
- W2984202313 creator A5040862836 @default.
- W2984202313 creator A5089633537 @default.
- W2984202313 date "2019-12-20" @default.
- W2984202313 modified "2023-10-01" @default.
- W2984202313 title "Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish" @default.
- W2984202313 cites W1030359021 @default.
- W2984202313 cites W1531113262 @default.
- W2984202313 cites W1569957341 @default.
- W2984202313 cites W1576281382 @default.
- W2984202313 cites W1898569975 @default.
- W2984202313 cites W1967747842 @default.
- W2984202313 cites W1970935798 @default.
- W2984202313 cites W1979878015 @default.
- W2984202313 cites W1981176067 @default.
- W2984202313 cites W1981408889 @default.
- W2984202313 cites W1987163665 @default.
- W2984202313 cites W1992874338 @default.
- W2984202313 cites W1998606948 @default.
- W2984202313 cites W2000916443 @default.
- W2984202313 cites W2002464261 @default.
- W2984202313 cites W2021215684 @default.
- W2984202313 cites W2035177738 @default.
- W2984202313 cites W2041414113 @default.
- W2984202313 cites W2056481952 @default.
- W2984202313 cites W2056818014 @default.
- W2984202313 cites W2056966070 @default.
- W2984202313 cites W2060004156 @default.
- W2984202313 cites W2060168659 @default.
- W2984202313 cites W2061652403 @default.
- W2984202313 cites W2069463594 @default.
- W2984202313 cites W2075238900 @default.
- W2984202313 cites W2085128107 @default.
- W2984202313 cites W2089984089 @default.
- W2984202313 cites W2102373264 @default.
- W2984202313 cites W2102467166 @default.
- W2984202313 cites W2102918221 @default.
- W2984202313 cites W2103101461 @default.
- W2984202313 cites W2107277218 @default.
- W2984202313 cites W2108522659 @default.
- W2984202313 cites W2116059196 @default.
- W2984202313 cites W2134836470 @default.
- W2984202313 cites W2135491132 @default.
- W2984202313 cites W2138396364 @default.
- W2984202313 cites W2141141014 @default.
- W2984202313 cites W2141368302 @default.
- W2984202313 cites W2149122802 @default.
- W2984202313 cites W2162542943 @default.
- W2984202313 cites W2263789901 @default.
- W2984202313 cites W2345804357 @default.
- W2984202313 cites W2399093613 @default.
- W2984202313 cites W2521757275 @default.
- W2984202313 cites W2524695962 @default.
- W2984202313 cites W2545616412 @default.
- W2984202313 cites W2619303664 @default.
- W2984202313 cites W2674875376 @default.
- W2984202313 cites W2771105349 @default.
- W2984202313 cites W2791633954 @default.
- W2984202313 cites W2887055255 @default.
- W2984202313 cites W2888722475 @default.
- W2984202313 cites W4236112869 @default.
- W2984202313 doi "https://doi.org/10.1242/jcs.236539" @default.
- W2984202313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7055366" @default.
- W2984202313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31722976" @default.
- W2984202313 hasPublicationYear "2019" @default.
- W2984202313 type Work @default.
- W2984202313 sameAs 2984202313 @default.
- W2984202313 citedByCount "20" @default.
- W2984202313 countsByYear W29842023132020 @default.
- W2984202313 countsByYear W29842023132021 @default.
- W2984202313 countsByYear W29842023132022 @default.
- W2984202313 countsByYear W29842023132023 @default.
- W2984202313 crossrefType "journal-article" @default.
- W2984202313 hasAuthorship W2984202313A5011009871 @default.
- W2984202313 hasAuthorship W2984202313A5019614963 @default.
- W2984202313 hasAuthorship W2984202313A5026436548 @default.
- W2984202313 hasAuthorship W2984202313A5037833836 @default.
- W2984202313 hasAuthorship W2984202313A5040862836 @default.
- W2984202313 hasAuthorship W2984202313A5089633537 @default.
- W2984202313 hasBestOaLocation W29842023131 @default.
- W2984202313 hasConcept C104317684 @default.
- W2984202313 hasConcept C136449434 @default.
- W2984202313 hasConcept C143065580 @default.
- W2984202313 hasConcept C181199279 @default.
- W2984202313 hasConcept C203014093 @default.
- W2984202313 hasConcept C2776878037 @default.
- W2984202313 hasConcept C2776914184 @default.
- W2984202313 hasConcept C2776923806 @default.
- W2984202313 hasConcept C2777700362 @default.
- W2984202313 hasConcept C2778175462 @default.
- W2984202313 hasConcept C2779719074 @default.
- W2984202313 hasConcept C2781308076 @default.
- W2984202313 hasConcept C38485361 @default.
- W2984202313 hasConcept C48349386 @default.
- W2984202313 hasConcept C55493867 @default.