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- W298423193 abstract "A series of experimental studies were carried out using Ehrlich ascites carcinoma. The radiosensitivity of those cells under such conditions were also studied. These results throw light on the problem of how the radiosensitivity of tumor cells is affected by the changes of the surrounding condition. Following death of the host, tumor cells are placed under anerobic conditions, but glycolysis is also inhibited. In the synthetic processes of nucleic acid, DNA synthesis was markedly inhibited shortly after death of the host, whereas RNA synthesis was maintained for a considerably prolonged period of time. In other words, it was suggested that the cessation of proliferation occurs within a short period of time, but the cellular function is maintained for a certain period of time. Furthermore, DNA synthesis which appeared to have been suspended after the death revived following the transplantation of cells to living mice. Within 6 hours of death, the uptake of trypan blue in tumor cells increased and at the same time DNase activity became remarkable. Six hours after the death of the host, the transplantability of tumor cells changed also. The oxygen tension in ascites in the group of dead mice showed significant decrease as compared with themore » control group (living mice), together with a significant decline in the body temperature. The PH of ascites of dead mice was lower than that of the control. The ascites was drawn from the dead mice irradiated in a dosage of 500 R and 1000 R 1, 2, and 3 hours after death, and from the irradiated living mice (control). These two kinds of ascites were transplanted intraperitoneally in one group (ascites form) and subcutaneously in another group (solid form) respectively. The survival of animals of the group transplanted with ascites from ihe dead mice was shortened as compared with the control. The weight of the solid tumor deriving from dead mice was also heavier than that of the control. From these experimental results, it may be possible to conclude that the irradiation on Ehrlich ascites carcinoma is less effective in the dead than in the living host. (auth)« less" @default.
- W298423193 created "2016-06-24" @default.
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- W298423193 date "1972-06-20" @default.
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- W298423193 title "Changes in Ehrlich ascites carcinoma after death of host mice. Changes of radiosensitivity of tumor cells" @default.
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