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- W2984236426 abstract "Roles of mitochondrial Na+-Ca2+ exchanger, NCLX, were studied in B lymphocytes such as heterozygous NCLX knockout DT40 cells, NCLX knockdown A20 cells, and native mouse spleen B lymphocytes treated with a NCLX blocker, CGP-37157. Cytosolic Ca2+ response to B cell receptor stimulation was impaired in these B lymphocytes, demonstrating importance of mitochondria-ER Ca2+ recycling via NCLX and sarco/endoplasmic reticulum Ca2+-ATPase SERCA, and interaction with store-operated Ca2+ entry. NCLX was also associated with motility and chemotaxis of B lymphocyte. Contrary to B lymphocytes, contribution of NCLX in mouse spleen T lymphocytes was minor." @default.
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- W2984236426 date "2020-01-01" @default.
- W2984236426 modified "2023-09-24" @default.
- W2984236426 title "Physiological functions of mitochondrial Na+-Ca2+ exchanger, NCLX, in lymphocytes" @default.
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- W2984236426 doi "https://doi.org/10.1016/j.ceca.2019.102114" @default.
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