FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984374510> ?p ?o ?g. }

• W2984374510 abstract "Multifocal breast cancer (MFBC), ductal type, has been hypothesized to arise by one of two mechanisms: either through intramammary/intralymphatic spread from a single index tumor (MBC-1), or as multiple independent tumors with each focus carrying its corresponding ductal carcinoma in-situ (MBC-2). In order to improve our understanding of MFBC pathogenesis, we employed laser capture microdissection coupled with whole-exome sequencing to study clonal origin in MFBC. We selected three cases of MBC-1 (C1 to C3) and MBC-2 (C4 to C6) and analyzed three foci from each case. MBC-1 cases were histologically similar and showed a strong predilection for satellite foci, vascular invasion and nodal metastasis when compared to MBC-2. Our bioinformatics approach provided strong evidence for clonal relationships in MBC-1, as demonstrated by distinct clusters of genes conserved across all tumor foci. Conversely, no gene clusters were shared across all the foci in MBC-2, suggesting multiple independent tumors. These findings provide further support for the two distinct pathogenetic mechanisms in MFBC." @default.
• W2984374510 created "2019-11-22" @default.
• W2984374510 creator A5005876190 @default.
• W2984374510 creator A5018038165 @default.
• W2984374510 creator A5018407483 @default.
• W2984374510 creator A5025018584 @default.
• W2984374510 creator A5073591942 @default.
• W2984374510 creator A5073836752 @default.
• W2984374510 creator A5078452073 @default.
• W2984374510 creator A5078904210 @default.
• W2984374510 creator A5084201785 @default.
• W2984374510 date "2019-12-01" @default.
• W2984374510 modified "2023-10-03" @default.
• W2984374510 title "Revisiting multifocal breast cancer: a clonality study of ductal carcinoma using whole exome sequencing" @default.
• W2984374510 cites W1975999486 @default.
• W2984374510 cites W1979384364 @default.
• W2984374510 cites W1984068087 @default.
• W2984374510 cites W1986589650 @default.
• W2984374510 cites W2006685639 @default.
• W2984374510 cites W2011422197 @default.
• W2984374510 cites W2014281161 @default.
• W2984374510 cites W2015182193 @default.
• W2984374510 cites W2018794125 @default.
• W2984374510 cites W2024108963 @default.
• W2984374510 cites W2038130580 @default.
• W2984374510 cites W2060934066 @default.
• W2984374510 cites W2066710246 @default.
• W2984374510 cites W2083794528 @default.
• W2984374510 cites W2084769634 @default.
• W2984374510 cites W2087268435 @default.
• W2984374510 cites W2091589496 @default.
• W2984374510 cites W2094604268 @default.
• W2984374510 cites W2097331151 @default.
• W2984374510 cites W2103441770 @default.
• W2984374510 cites W2128237178 @default.
• W2984374510 cites W2128505445 @default.
• W2984374510 cites W2131271579 @default.
• W2984374510 cites W2147796195 @default.
• W2984374510 cites W2168133698 @default.
• W2984374510 cites W2430708772 @default.
• W2984374510 cites W2553167374 @default.
• W2984374510 cites W2801591211 @default.
• W2984374510 doi "https://doi.org/10.1016/j.humpath.2019.08.021" @default.
• W2984374510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31704365" @default.
• W2984374510 hasPublicationYear "2019" @default.
• W2984374510 type Work @default.
• W2984374510 sameAs 2984374510 @default.
• W2984374510 citedByCount "0" @default.
• W2984374510 crossrefType "journal-article" @default.
• W2984374510 hasAuthorship W2984374510A5005876190 @default.
• W2984374510 hasAuthorship W2984374510A5018038165 @default.
• W2984374510 hasAuthorship W2984374510A5018407483 @default.
• W2984374510 hasAuthorship W2984374510A5025018584 @default.
• W2984374510 hasAuthorship W2984374510A5073591942 @default.
• W2984374510 hasAuthorship W2984374510A5073836752 @default.
• W2984374510 hasAuthorship W2984374510A5078452073 @default.
• W2984374510 hasAuthorship W2984374510A5078904210 @default.
• W2984374510 hasAuthorship W2984374510A5084201785 @default.
• W2984374510 hasConcept C104317684 @default.
• W2984374510 hasConcept C11242284 @default.
• W2984374510 hasConcept C121608353 @default.
• W2984374510 hasConcept C125965507 @default.
• W2984374510 hasConcept C127716648 @default.
• W2984374510 hasConcept C142724271 @default.
• W2984374510 hasConcept C150194340 @default.
• W2984374510 hasConcept C16671776 @default.
• W2984374510 hasConcept C2777546739 @default.
• W2984374510 hasConcept C2779013556 @default.
• W2984374510 hasConcept C2780862961 @default.
• W2984374510 hasConcept C530470458 @default.
• W2984374510 hasConcept C54355233 @default.
• W2984374510 hasConcept C71924100 @default.
• W2984374510 hasConcept C86803240 @default.
• W2984374510 hasConceptScore W2984374510C104317684 @default.
• W2984374510 hasConceptScore W2984374510C11242284 @default.
• W2984374510 hasConceptScore W2984374510C121608353 @default.
• W2984374510 hasConceptScore W2984374510C125965507 @default.
• W2984374510 hasConceptScore W2984374510C127716648 @default.
• W2984374510 hasConceptScore W2984374510C142724271 @default.
• W2984374510 hasConceptScore W2984374510C150194340 @default.
• W2984374510 hasConceptScore W2984374510C16671776 @default.
• W2984374510 hasConceptScore W2984374510C2777546739 @default.
• W2984374510 hasConceptScore W2984374510C2779013556 @default.
• W2984374510 hasConceptScore W2984374510C2780862961 @default.
• W2984374510 hasConceptScore W2984374510C530470458 @default.
• W2984374510 hasConceptScore W2984374510C54355233 @default.
• W2984374510 hasConceptScore W2984374510C71924100 @default.
• W2984374510 hasConceptScore W2984374510C86803240 @default.
• W2984374510 hasLocation W29843745101 @default.
• W2984374510 hasLocation W29843745102 @default.
• W2984374510 hasOpenAccess W2984374510 @default.
• W2984374510 hasPrimaryLocation W29843745101 @default.
• W2984374510 hasRelatedWork W1976626519 @default.
• W2984374510 hasRelatedWork W2019155015 @default.
• W2984374510 hasRelatedWork W2056494711 @default.
• W2984374510 hasRelatedWork W2119207326 @default.
• W2984374510 hasRelatedWork W2312304967 @default.
• W2984374510 hasRelatedWork W2559971472 @default.
• W2984374510 hasRelatedWork W2889577155 @default.
• W2984374510 hasRelatedWork W2907445345 @default.

• next