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- W2984567701 endingPage "3726" @default.
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- W2984567701 abstract "3726 Small animals such as mice and rats are very good models in biomedical research on cancer, especially when non-invasive in vivo imaging is used. Virtually every biomedical research institute and pharmaceutical company now has small animal imaging facilities that support scientists’ studies. Infection, especially pinworm infection, is a very serious issue that each animal facility tries to prevent and has to face and manage. Fenbendazole (FBZ), a type of anthelmintic drug, is often used to treat various gastrointestinal parasites including roundworms, hookworms, whipworms, the taenia species of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides. It is also effective against Giardia, a protozoan and several species of lungworm and even some flukes. In order to prevent pinword infection in animal housing facilities in the long run, especially for longitudinal animal imaging studies, it has been suggested that all mice and rats be given fenbendazole-containing feed, on a prophylactic basis. However, fenendazole is a fluorescent compound that may contribute to background in imaging studies. We evaluated whether fenbendazole in the food interferes with fluorescence optical imaging signals of interest. Our preliminary data show a strong fenbendazole fluorescent signal in the mouse belly area that might interfere or overlap with the region of interest of a particular study. Using measurements of fluorescence intensity or fluorescence life-time imaging, it is clear that fenbendazole-containing diets contribute to high background signal in the gastrointestinal tract of imaged living mice. More research is required to develop strategies to reduce or eliminate this background which could improve the sensitivity and specificity of in vivo imaging studies." @default.
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- W2984567701 date "2008-05-01" @default.
- W2984567701 modified "2023-09-28" @default.
- W2984567701 title "Observation of fenbendazole fluorescent effect in small animal optical imaging" @default.
- W2984567701 hasPublicationYear "2008" @default.
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