FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984667955> ?p ?o ?g. }

• W2984667955 endingPage "e0224351" @default.
• W2984667955 startingPage "e0224351" @default.
• W2984667955 abstract "To estimate the cost-effectiveness of available diagnosis alternatives for Mucosal Leishmaniasis (ML) in Colombian suspected patients. A simulation model of the disease's natural history was built with a decision tree and Markov models. The model´s parameters were identified by systematic review and validated by expert consensus. A bottom-up cost analysis to estimate the costs of diagnostic strategies and treatment per case was performed by reviewing 48 clinical records of patients diagnosed with ML. The diagnostic strategies compared were as follows: 1) no diagnosis; 2) parasite culture, biopsy, indirect immunofluorescence assay (IFA), and Montenegro skin test (MST) combined ; 3) parasite culture, biopsy, and IFA combined; 4) PCR-miniexon; and 5) PCR-kDNA. Three scenarios were modeled in patients with ML clinical suspicion, according to ML prevalence scenarios: high, medium and low. Adjusted sensitivity and specificity parameters of a combination of diagnostic tests were estimated with a discrete event simulation (DES) model. For each alternative, the costs and health outcomes were estimated. The time horizon was life expectancy, considering the average age at diagnosis of 31 years. Incremental cost-effectiveness ratios (ICERs) were calculated per Disability Life Year (DALY) avoided, and deterministic and probabilistic sensitivity analyses were performed. A threshold of willingness to pay (WTP) of three-time gross domestic product per capita (GDPpc) (US$ 15,795) and a discount rate of 3% was considered. The analysis perspective was the third payer (Health System). All costs were reported in American dollars as of 2015. PCR- kDNA was the cost-effective alternative in clinical suspicion levels: low, medium and high with ICERs of US$ 7,909.39, US$ 5,559.33 and US$ 4,458.92 per DALY avoided, respectively. ML diagnostic tests based on PCR are cost-effective strategies, regardless of the level of clinical suspicion. PCR-kDNA was the most cost-effective strategy in the competitive scenario with the parameters included in the present model." @default.
• W2984667955 created "2019-11-22" @default.
• W2984667955 creator A5030251750 @default.
• W2984667955 creator A5049798741 @default.
• W2984667955 creator A5053836564 @default.
• W2984667955 creator A5063931273 @default.
• W2984667955 creator A5087396761 @default.
• W2984667955 creator A5027500301 @default.
• W2984667955 date "2019-11-04" @default.
• W2984667955 modified "2023-10-15" @default.
• W2984667955 title "Cost-effectiveness analysis of Mucosal Leishmaniasis diagnosis with PCR-based vs parasitological tests in Colombia" @default.
• W2984667955 cites W166169566 @default.
• W2984667955 cites W1966851401 @default.
• W2984667955 cites W1976174823 @default.
• W2984667955 cites W1977045618 @default.
• W2984667955 cites W1977066985 @default.
• W2984667955 cites W1994517371 @default.
• W2984667955 cites W2001129672 @default.
• W2984667955 cites W2001373329 @default.
• W2984667955 cites W2003628236 @default.
• W2984667955 cites W2006062762 @default.
• W2984667955 cites W2011238040 @default.
• W2984667955 cites W2029036450 @default.
• W2984667955 cites W2038850624 @default.
• W2984667955 cites W2040598188 @default.
• W2984667955 cites W2041772463 @default.
• W2984667955 cites W2051649254 @default.
• W2984667955 cites W2055603804 @default.
• W2984667955 cites W2063318491 @default.
• W2984667955 cites W2077981550 @default.
• W2984667955 cites W2081270789 @default.
• W2984667955 cites W2085574734 @default.
• W2984667955 cites W2090673472 @default.
• W2984667955 cites W2090961207 @default.
• W2984667955 cites W2104391714 @default.
• W2984667955 cites W2110706456 @default.
• W2984667955 cites W2111128804 @default.
• W2984667955 cites W2127052921 @default.
• W2984667955 cites W2127474760 @default.
• W2984667955 cites W2144009726 @default.
• W2984667955 cites W2144964613 @default.
• W2984667955 cites W2155917495 @default.
• W2984667955 cites W2155940319 @default.
• W2984667955 cites W2167468313 @default.
• W2984667955 cites W2178179846 @default.
• W2984667955 cites W2343014459 @default.
• W2984667955 cites W2398273816 @default.
• W2984667955 cites W2403322038 @default.
• W2984667955 cites W2407330064 @default.
• W2984667955 cites W2518806666 @default.
• W2984667955 cites W2557867537 @default.
• W2984667955 cites W2626772760 @default.
• W2984667955 cites W2689578640 @default.
• W2984667955 cites W2804488909 @default.
• W2984667955 cites W4322700381 @default.
• W2984667955 doi "https://doi.org/10.1371/journal.pone.0224351" @default.
• W2984667955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6827906" @default.
• W2984667955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31682606" @default.
• W2984667955 hasPublicationYear "2019" @default.
• W2984667955 type Work @default.
• W2984667955 sameAs 2984667955 @default.
• W2984667955 citedByCount "3" @default.
• W2984667955 countsByYear W29846679552019 @default.
• W2984667955 countsByYear W29846679552022 @default.
• W2984667955 crossrefType "journal-article" @default.
• W2984667955 hasAuthorship W2984667955A5027500301 @default.
• W2984667955 hasAuthorship W2984667955A5030251750 @default.
• W2984667955 hasAuthorship W2984667955A5049798741 @default.
• W2984667955 hasAuthorship W2984667955A5053836564 @default.
• W2984667955 hasAuthorship W2984667955A5063931273 @default.
• W2984667955 hasAuthorship W2984667955A5087396761 @default.
• W2984667955 hasBestOaLocation W29846679551 @default.
• W2984667955 hasConcept C112930515 @default.
• W2984667955 hasConcept C121117317 @default.
• W2984667955 hasConcept C126322002 @default.
• W2984667955 hasConcept C138816342 @default.
• W2984667955 hasConcept C142724271 @default.
• W2984667955 hasConcept C160798450 @default.
• W2984667955 hasConcept C2776555147 @default.
• W2984667955 hasConcept C2778049256 @default.
• W2984667955 hasConcept C2779134260 @default.
• W2984667955 hasConcept C2780664029 @default.
• W2984667955 hasConcept C3019080777 @default.
• W2984667955 hasConcept C44249647 @default.
• W2984667955 hasConcept C515549039 @default.
• W2984667955 hasConcept C524218345 @default.
• W2984667955 hasConcept C71924100 @default.
• W2984667955 hasConceptScore W2984667955C112930515 @default.
• W2984667955 hasConceptScore W2984667955C121117317 @default.
• W2984667955 hasConceptScore W2984667955C126322002 @default.
• W2984667955 hasConceptScore W2984667955C138816342 @default.
• W2984667955 hasConceptScore W2984667955C142724271 @default.
• W2984667955 hasConceptScore W2984667955C160798450 @default.
• W2984667955 hasConceptScore W2984667955C2776555147 @default.
• W2984667955 hasConceptScore W2984667955C2778049256 @default.
• W2984667955 hasConceptScore W2984667955C2779134260 @default.
• W2984667955 hasConceptScore W2984667955C2780664029 @default.
• W2984667955 hasConceptScore W2984667955C3019080777 @default.

• next