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- W2984702961 abstract "Abstract Palytoxin (PTX), isolated from zoanthid Palytoha sp., is one of the most potent marine toxins. The mode of norepinephrine (NE) releasing action of PTX was investigated using a rat pheochromocytoma cell line (PC12). PTX caused a dose-dependent release of 3H-NE from PCl2. This release was markedly inhibited by Co2+ or Ca2+-free medium, but was not affected by tetrodotoxin (TTX). The release of 3H-NE induced by a low dose (3×10−8M) of PTX was abolished in Na-free medium and increased as external Na+ was raised from 3 to 100 mM, but the NE release by a high dose (10−6 M) was not affected by varying the concentrations of Na+ from 0 to 100 mM. The release of 3H-NE induced by both doses of PTX increased with increasing external Ca2+ from 0 to 3 mM. PTX caused a dose-dependent increase in 22Na and 45Ca influx into PCl2 cells at concentration of 10−10 - 10−8 M and 10−9 - 10−6 M, respectively. The PTX-induced 45Ca influx was markedly inhibited by Co2+, while the PTX-induced 22Na influx was not affected by TTX. These results suggest that the NE release induced by lower doses of PTX is primarily brought about by increasing TTX-insensitive Na+ permeability across the cell membrane of PCl2 cells, whereas that by higher doses is mainly due to a direct increase in Ca influx into them." @default.
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- W2984702961 date "1983-01-01" @default.
- W2984702961 modified "2023-10-08" @default.
- W2984702961 title "Mechanism of the 3H-Norepinephrine Release Induced by Palytoxin from a Rat Pheochromocytoma Cell Line." @default.
- W2984702961 doi "https://doi.org/10.1016/s0021-5198(19)64906-1" @default.
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