Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984766800> ?p ?o ?g. }
- W2984766800 abstract "B cell lymphoma is a clinically heterogeneous and pathologically diverse group of diseases with a strong epigenetic component. The B cell lymphoma 6 (BCL6) gene encodes a transcription factor that is critical for normal germinal center reaction B cell development by maintaining an epigenetic and transcriptional state that is permissive for cellular proliferation and DNA damage. The activity of BCL6 can be deregulated by a variety of mechanisms and contributes to the development of B-cell lymphoma. Here we review the direct and indirect mechanisms BCL6 dysregulation in B cell lymphoma, including transcriptional and post-translational regulation of BCL6 expression and activity, and the perturbation of BCL6-regulated epigenetic programs by cooperating chromatin modifying gene mutations. We underscore the critical importance of BCL6 and its associated epigenetic programs in the development of B-cell lymphoma, and discuss avenues for the therapeutic targeting of BCL6 in this context." @default.
- W2984766800 created "2019-11-22" @default.
- W2984766800 creator A5026939161 @default.
- W2984766800 creator A5060605798 @default.
- W2984766800 date "2019-11-07" @default.
- W2984766800 modified "2023-10-15" @default.
- W2984766800 title "Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation" @default.
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- W2984766800 doi "https://doi.org/10.3389/fcell.2019.00272" @default.
- W2984766800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6853842" @default.
- W2984766800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31788471" @default.
- W2984766800 hasPublicationYear "2019" @default.
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