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- W2984830533 startingPage "2084" @default.
- W2984830533 abstract "Although intensive efforts have been devoted to investigating latent tuberculosis (LTB) and active tuberculosis (PTB) infections, the similarities and differences in the host responses to these two closely associated stages remain elusive, probably due to the difficulty in identifying informative genes related to LTB using traditional methods. Herein, we developed a framework known as the consistently differential expression network to identify tuberculosis (TB)-related gene pairs by combining microarray profiles and protein-protein interactions. We thus obtained 774 and 693 pairs corresponding to the PTB and LTB stages, respectively. The PTB-specific genes showed higher expression values and fold-changes than the LTB-specific genes. Furthermore, the PTB-related pairs generally had higher expression correlations and would be more activated compared to their LTB-related counterparts. The module analysis implied that the detected gene pairs tended to cluster in the topological and functional modules. Functional analysis indicated that the LTB- and PTB-specific genes were enriched in different pathways and had remarkably different locations in the NF-κB signaling pathway. Finally, we showed that the identified genes and gene pairs had the potential to distinguish TB patients in different disease stages and could be considered as drug targets for the specific treatment of patients with LTB or PTB." @default.
- W2984830533 created "2019-11-22" @default.
- W2984830533 creator A5008171524 @default.
- W2984830533 creator A5018636031 @default.
- W2984830533 creator A5058311447 @default.
- W2984830533 creator A5079203625 @default.
- W2984830533 date "2019-11-13" @default.
- W2984830533 modified "2023-10-12" @default.
- W2984830533 title "Decoding the similarities and specific differences between latent and active tuberculosis infections based on consistently differential expression networks" @default.
- W2984830533 cites W1506007859 @default.
- W2984830533 cites W1506303504 @default.
- W2984830533 cites W1578104218 @default.
- W2984830533 cites W1598824760 @default.
- W2984830533 cites W1752753809 @default.
- W2984830533 cites W1853452392 @default.
- W2984830533 cites W1884732005 @default.
- W2984830533 cites W1932590484 @default.
- W2984830533 cites W1938351738 @default.
- W2984830533 cites W1949882695 @default.
- W2984830533 cites W1966020578 @default.
- W2984830533 cites W1966573914 @default.
- W2984830533 cites W1969623044 @default.
- W2984830533 cites W1971528695 @default.
- W2984830533 cites W1982819380 @default.
- W2984830533 cites W1991356932 @default.
- W2984830533 cites W1993600630 @default.
- W2984830533 cites W1994313705 @default.
- W2984830533 cites W1998443306 @default.
- W2984830533 cites W2001454891 @default.
- W2984830533 cites W2004130935 @default.
- W2984830533 cites W2007405611 @default.
- W2984830533 cites W2008152110 @default.
- W2984830533 cites W2008547756 @default.
- W2984830533 cites W2009313526 @default.
- W2984830533 cites W2013986436 @default.
- W2984830533 cites W2025498302 @default.
- W2984830533 cites W2029335938 @default.
- W2984830533 cites W2032006072 @default.
- W2984830533 cites W2033693656 @default.
- W2984830533 cites W2036369755 @default.
- W2984830533 cites W2048492877 @default.
- W2984830533 cites W2055706365 @default.
- W2984830533 cites W2059405490 @default.
- W2984830533 cites W2060705109 @default.
- W2984830533 cites W2063967619 @default.
- W2984830533 cites W2064560169 @default.
- W2984830533 cites W2067503622 @default.
- W2984830533 cites W2069733150 @default.
- W2984830533 cites W2071857026 @default.
- W2984830533 cites W2088422296 @default.
- W2984830533 cites W2088650124 @default.
- W2984830533 cites W2091015733 @default.
- W2984830533 cites W2102152191 @default.
- W2984830533 cites W2102545006 @default.
- W2984830533 cites W2102764186 @default.
- W2984830533 cites W2106462617 @default.
- W2984830533 cites W2107665951 @default.
- W2984830533 cites W2109244892 @default.
- W2984830533 cites W2109543073 @default.
- W2984830533 cites W2110799129 @default.
- W2984830533 cites W2110807603 @default.
- W2984830533 cites W2116547678 @default.
- W2984830533 cites W2118502498 @default.
- W2984830533 cites W2122863289 @default.
- W2984830533 cites W2124166542 @default.
- W2984830533 cites W2130687290 @default.
- W2984830533 cites W2131858707 @default.
- W2984830533 cites W2131991643 @default.
- W2984830533 cites W2132008404 @default.
- W2984830533 cites W2136626725 @default.
- W2984830533 cites W2137095795 @default.
- W2984830533 cites W2140242713 @default.
- W2984830533 cites W2145559868 @default.
- W2984830533 cites W2163568386 @default.
- W2984830533 cites W2164251428 @default.
- W2984830533 cites W2169448470 @default.
- W2984830533 cites W2221976450 @default.
- W2984830533 cites W2223396556 @default.
- W2984830533 cites W2238290008 @default.
- W2984830533 cites W2239423944 @default.
- W2984830533 cites W2266672344 @default.
- W2984830533 cites W2285903333 @default.
- W2984830533 cites W2310773425 @default.
- W2984830533 cites W2312699066 @default.
- W2984830533 cites W2317035559 @default.
- W2984830533 cites W2337546788 @default.
- W2984830533 cites W2475036636 @default.
- W2984830533 cites W2521110192 @default.
- W2984830533 cites W2531028337 @default.
- W2984830533 cites W2534390616 @default.
- W2984830533 cites W2561418870 @default.
- W2984830533 cites W2586070549 @default.
- W2984830533 cites W2617363144 @default.
- W2984830533 cites W2622825521 @default.
- W2984830533 cites W2656688707 @default.
- W2984830533 cites W2773178464 @default.
- W2984830533 cites W2782795252 @default.
- W2984830533 cites W2791740753 @default.