FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984860428> ?p ?o ?g. }

• W2984860428 abstract "Background Mineralocorticoid receptor antagonists ( MRA s) have emerged as potential atrial fibrillation ( AF ) preventive therapy, but inconsistent results have been reported. We aimed to examine the effects of MRA s on AF occurrence and explore factors that could influence the magnitude of the effect size. Methods and Results PubMed, Embase, and Cochrane Central databases were used to search for randomized clinical trials and observational studies addressing the effect of MRA s on AF occurrence from database inception through April 03, 2018. We performed a systematic review and random effects meta‐analyses to compute odds ratios with 95% CI s. Meta‐regression was then applied to explore the sources of between‐study heterogeneity. We included 24 studies, 11 randomized clinical trials and 13 observational cohorts, representing a total number of 7914 patients (median age: 64.2 years; median left ventricular ejection fraction: 49.7%; median follow‐up: 12.0 months), 2843 (35.9%) of whom received MRA therapy. Meta‐analyses showed a significant overall reduction in AF occurrence in the MRA ‐treated patients versus the control groups (15.0% versus 32.2%; odds ratio, 0.55; 95% CI , 0.44–0.70 [ P <0.00001]), with the greatest benefit regarding recurrent AF episodes ( odds ratio , 0.42; 95% CI , 0.31–0.59 [ P <0.00001]) and with significant heterogeneity among the included studies ( I 2 =54%; P =0.0008). Meta‐regression analyses showed that effect size was significantly associated with older studies and higher AF occurrence rate in the control groups. Conclusions MRA s seem to be effective in AF prevention, especially regarding recurrent AF episodes." @default.
• W2984860428 created "2019-11-22" @default.
• W2984860428 creator A5009144174 @default.
• W2984860428 creator A5012092356 @default.
• W2984860428 creator A5025741157 @default.
• W2984860428 creator A5026143127 @default.
• W2984860428 creator A5027731973 @default.
• W2984860428 creator A5029201551 @default.
• W2984860428 creator A5032245948 @default.
• W2984860428 creator A5039965458 @default.
• W2984860428 creator A5053303683 @default.
• W2984860428 creator A5053948267 @default.
• W2984860428 creator A5067055109 @default.
• W2984860428 creator A5071495161 @default.
• W2984860428 creator A5082323092 @default.
• W2984860428 creator A5082491469 @default.
• W2984860428 date "2019-11-19" @default.
• W2984860428 modified "2023-10-16" @default.
• W2984860428 title "Effects of Mineralocorticoid Receptor Antagonists on Atrial Fibrillation Occurrence: A Systematic Review, Meta‐Analysis, and Meta‐Regression to Identify Modifying Factors" @default.
• W2984860428 cites W1568095913 @default.
• W2984860428 cites W1850125129 @default.
• W2984860428 cites W1976598631 @default.
• W2984860428 cites W1995373017 @default.
• W2984860428 cites W2012170732 @default.
• W2984860428 cites W2018067295 @default.
• W2984860428 cites W2025255734 @default.
• W2984860428 cites W2037407174 @default.
• W2984860428 cites W2038180440 @default.
• W2984860428 cites W2069970774 @default.
• W2984860428 cites W2080922412 @default.
• W2984860428 cites W2090472532 @default.
• W2984860428 cites W2091894128 @default.
• W2984860428 cites W2097198666 @default.
• W2984860428 cites W2098923148 @default.
• W2984860428 cites W2115871372 @default.
• W2984860428 cites W2137446080 @default.
• W2984860428 cites W2144851822 @default.
• W2984860428 cites W2153675516 @default.
• W2984860428 cites W2156497356 @default.
• W2984860428 cites W2167423131 @default.
• W2984860428 cites W2169205464 @default.
• W2984860428 cites W2265390416 @default.
• W2984860428 cites W2486747697 @default.
• W2984860428 cites W2518524066 @default.
• W2984860428 cites W2530976845 @default.
• W2984860428 cites W2531269403 @default.
• W2984860428 cites W2542960621 @default.
• W2984860428 cites W2561094410 @default.
• W2984860428 cites W2745570199 @default.
• W2984860428 cites W2765289415 @default.
• W2984860428 cites W2803805547 @default.
• W2984860428 cites W2825330605 @default.
• W2984860428 doi "https://doi.org/10.1161/jaha.119.013267" @default.
• W2984860428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6915291" @default.
• W2984860428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31711383" @default.
• W2984860428 hasPublicationYear "2019" @default.
• W2984860428 type Work @default.
• W2984860428 sameAs 2984860428 @default.
• W2984860428 citedByCount "20" @default.
• W2984860428 countsByYear W29848604282020 @default.
• W2984860428 countsByYear W29848604282021 @default.
• W2984860428 countsByYear W29848604282022 @default.
• W2984860428 countsByYear W29848604282023 @default.
• W2984860428 crossrefType "journal-article" @default.
• W2984860428 hasAuthorship W2984860428A5009144174 @default.
• W2984860428 hasAuthorship W2984860428A5012092356 @default.
• W2984860428 hasAuthorship W2984860428A5025741157 @default.
• W2984860428 hasAuthorship W2984860428A5026143127 @default.
• W2984860428 hasAuthorship W2984860428A5027731973 @default.
• W2984860428 hasAuthorship W2984860428A5029201551 @default.
• W2984860428 hasAuthorship W2984860428A5032245948 @default.
• W2984860428 hasAuthorship W2984860428A5039965458 @default.
• W2984860428 hasAuthorship W2984860428A5053303683 @default.
• W2984860428 hasAuthorship W2984860428A5053948267 @default.
• W2984860428 hasAuthorship W2984860428A5067055109 @default.
• W2984860428 hasAuthorship W2984860428A5071495161 @default.
• W2984860428 hasAuthorship W2984860428A5082323092 @default.
• W2984860428 hasAuthorship W2984860428A5082491469 @default.
• W2984860428 hasBestOaLocation W29848604281 @default.
• W2984860428 hasConcept C119423318 @default.
• W2984860428 hasConcept C124936440 @default.
• W2984860428 hasConcept C126322002 @default.
• W2984860428 hasConcept C156957248 @default.
• W2984860428 hasConcept C164705383 @default.
• W2984860428 hasConcept C168563851 @default.
• W2984860428 hasConcept C23131810 @default.
• W2984860428 hasConcept C2779161974 @default.
• W2984860428 hasConcept C71924100 @default.
• W2984860428 hasConcept C95190672 @default.
• W2984860428 hasConceptScore W2984860428C119423318 @default.
• W2984860428 hasConceptScore W2984860428C124936440 @default.
• W2984860428 hasConceptScore W2984860428C126322002 @default.
• W2984860428 hasConceptScore W2984860428C156957248 @default.
• W2984860428 hasConceptScore W2984860428C164705383 @default.
• W2984860428 hasConceptScore W2984860428C168563851 @default.
• W2984860428 hasConceptScore W2984860428C23131810 @default.
• W2984860428 hasConceptScore W2984860428C2779161974 @default.
• W2984860428 hasConceptScore W2984860428C71924100 @default.
• W2984860428 hasConceptScore W2984860428C95190672 @default.
• W2984860428 hasIssue "22" @default.

• next