FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984861736> ?p ?o ?g. }

• W2984861736 abstract "Abstract Background Dynamic N 6 -methyladenosine (m 6 A) RNA modification generated and erased by N 6 -methyltransferases and demethylases regulates gene expression, alternative splicing and cell fate. Ocular melanoma, comprising uveal melanoma (UM) and conjunctival melanoma (CM), is the most common primary eye tumor in adults and the 2nd most common melanoma. However, the functional role of m 6 A modification in ocular melanoma remains unclear. Methods m 6 A assays and survival analysis were used to explore decreased global m 6 A levels, indicating a late stage of ocular melanoma and a poor prognosis. Multiomic analysis of miCLIP-seq, RNA-seq and Label-free MS data revealed that m 6 A RNA modification posttranscriptionally promoted HINT2 expression. RNA immunoprecipitation (RIP)-qPCR and dual luciferase assays revealed that HINT2 mRNA specifically interacted with YTHDF1. Furthermore, polysome profiling analysis indicated a greater amount of HINT2 mRNA in the translation pool in ocular melanoma cells with higher m 6 A methylation. Results Here, we show that RNA methylation significantly inhibits the progression of UM and CM. Ocular melanoma samples showed decreased m 6 A levels, indicating a poor prognosis. Changes in global m 6 A modification were highly associated with tumor progression in vitro and in vivo. Mechanistically, YTHDF1 promoted the translation of methylated HINT2 mRNA, a tumor suppressor in ocular melanoma. Conclusions Our work uncovers a critical function for m 6 A methylation in ocular melanoma and provides additional insight into the understanding of m 6 A modification." @default.
• W2984861736 created "2019-11-22" @default.
• W2984861736 creator A5005989724 @default.
• W2984861736 creator A5029619952 @default.
• W2984861736 creator A5044641119 @default.
• W2984861736 creator A5052037541 @default.
• W2984861736 creator A5058592281 @default.
• W2984861736 creator A5059905157 @default.
• W2984861736 creator A5061702878 @default.
• W2984861736 creator A5085206645 @default.
• W2984861736 creator A5087221150 @default.
• W2984861736 date "2019-11-14" @default.
• W2984861736 modified "2023-10-14" @default.
• W2984861736 title "m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation" @default.
• W2984861736 cites W1977647140 @default.
• W2984861736 cites W1977995175 @default.
• W2984861736 cites W1981629946 @default.
• W2984861736 cites W1987462530 @default.
• W2984861736 cites W1991807334 @default.
• W2984861736 cites W2011131953 @default.
• W2984861736 cites W2014677321 @default.
• W2984861736 cites W2021699617 @default.
• W2984861736 cites W2036897871 @default.
• W2984861736 cites W2039939270 @default.
• W2984861736 cites W2054101905 @default.
• W2984861736 cites W2055835855 @default.
• W2984861736 cites W2071930821 @default.
• W2984861736 cites W2102278945 @default.
• W2984861736 cites W2102619694 @default.
• W2984861736 cites W2103441770 @default.
• W2984861736 cites W2112248128 @default.
• W2984861736 cites W2114893730 @default.
• W2984861736 cites W2118349725 @default.
• W2984861736 cites W2131271579 @default.
• W2984861736 cites W2137318078 @default.
• W2984861736 cites W2138207763 @default.
• W2984861736 cites W2150631733 @default.
• W2984861736 cites W2166771927 @default.
• W2984861736 cites W2171808845 @default.
• W2984861736 cites W2179438025 @default.
• W2984861736 cites W2313104165 @default.
• W2984861736 cites W2326441340 @default.
• W2984861736 cites W2328462791 @default.
• W2984861736 cites W2342299314 @default.
• W2984861736 cites W2399233355 @default.
• W2984861736 cites W2533922074 @default.
• W2984861736 cites W2558981096 @default.
• W2984861736 cites W2559344646 @default.
• W2984861736 cites W2563912688 @default.
• W2984861736 cites W2575691519 @default.
• W2984861736 cites W2576374552 @default.
• W2984861736 cites W2597021695 @default.
• W2984861736 cites W2600626962 @default.
• W2984861736 cites W2600862208 @default.
• W2984861736 cites W2606518593 @default.
• W2984861736 cites W2627064270 @default.
• W2984861736 cites W2749219966 @default.
• W2984861736 cites W2751668414 @default.
• W2984861736 cites W2754499625 @default.
• W2984861736 cites W2756412602 @default.
• W2984861736 cites W2757839170 @default.
• W2984861736 cites W2761676504 @default.
• W2984861736 cites W2764301500 @default.
• W2984861736 cites W2769630486 @default.
• W2984861736 cites W2770747479 @default.
• W2984861736 cites W2772792536 @default.
• W2984861736 cites W2776540408 @default.
• W2984861736 cites W2793234561 @default.
• W2984861736 cites W2793598502 @default.
• W2984861736 cites W2793785833 @default.
• W2984861736 cites W2803154276 @default.
• W2984861736 cites W2807347076 @default.
• W2984861736 cites W2883872430 @default.
• W2984861736 cites W2886253007 @default.
• W2984861736 cites W2890140563 @default.
• W2984861736 cites W2897208044 @default.
• W2984861736 cites W2942199823 @default.
• W2984861736 cites W2945580636 @default.
• W2984861736 cites W2955121251 @default.
• W2984861736 cites W2972178290 @default.
• W2984861736 cites W4238719510 @default.
• W2984861736 cites W776567260 @default.
• W2984861736 doi "https://doi.org/10.1186/s12943-019-1088-x" @default.
• W2984861736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6854757" @default.
• W2984861736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31722709" @default.
• W2984861736 hasPublicationYear "2019" @default.
• W2984861736 type Work @default.
• W2984861736 sameAs 2984861736 @default.
• W2984861736 citedByCount "102" @default.
• W2984861736 countsByYear W29848617362019 @default.
• W2984861736 countsByYear W29848617362020 @default.
• W2984861736 countsByYear W29848617362021 @default.
• W2984861736 countsByYear W29848617362022 @default.
• W2984861736 countsByYear W29848617362023 @default.
• W2984861736 crossrefType "journal-article" @default.
• W2984861736 hasAuthorship W2984861736A5005989724 @default.
• W2984861736 hasAuthorship W2984861736A5029619952 @default.
• W2984861736 hasAuthorship W2984861736A5044641119 @default.
• W2984861736 hasAuthorship W2984861736A5052037541 @default.
• W2984861736 hasAuthorship W2984861736A5058592281 @default.

• next