FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984918847> ?p ?o ?g. }

• W2984918847 abstract "Abstract Sensitive and objective biomarkers of neuronal injury, degeneration, and regeneration can help facilitate translation of experimental findings into clinical testing. Whereas measures of upper motor neuron connectivity have been readily established, functional assessments of lower motor neuron (LMN) innervation of forelimb muscles are lacking. Compound muscle action potential (CMAP) and motor unit (MU) number estimation (MUNE) are well-established methods that allow longitudinal MU integrity monitoring in patients. In analogy we refined CMAP and MUNE methods for assessing spinal MU input in the rat forelimb and hindlimb. Repeated CMAP and MUNE recordings are robust (coefficients of variability: 4.5–11.3%), and MUNE measurements from forelimb wrist flexor muscles (415 ± 8 [SEM]) align with back-traced anatomical LMN counts (336 ± 16 [SEM]). For disease validation, cross-sectional blinded electrophysiological and muscle contractility measurements were obtained in a cohort of G93A SOD1 mutant overexpressing rats and compared with controls. Longitudinal assessment of mutant animals demonstrated progressive motor unit decline in the hindlimb to a greater extent than the forelimb. Hindlimb CMAP and MUNE demonstrated strong correlations with plantarflexion muscle contractility. Cross-species assessment of upper/fore- limb and lower/hind- limb motor units using objective electrophysiological CMAP and MUNE values as biomarkers will guide and improve bi-directional translation." @default.
• W2984918847 created "2019-11-22" @default.
• W2984918847 creator A5011205540 @default.
• W2984918847 creator A5016640472 @default.
• W2984918847 creator A5030192831 @default.
• W2984918847 creator A5037467517 @default.
• W2984918847 creator A5047920066 @default.
• W2984918847 creator A5063660131 @default.
• W2984918847 date "2019-11-13" @default.
• W2984918847 modified "2023-09-26" @default.
• W2984918847 title "Assessing Rat Forelimb and Hindlimb Motor Unit Connectivity as Objective and Robust Biomarkers of Spinal Motor Neuron Function" @default.
• W2984918847 cites W1146531556 @default.
• W2984918847 cites W1475604916 @default.
• W2984918847 cites W1538003228 @default.
• W2984918847 cites W1677870144 @default.
• W2984918847 cites W1895834348 @default.
• W2984918847 cites W1912693339 @default.
• W2984918847 cites W1975039972 @default.
• W2984918847 cites W1979846555 @default.
• W2984918847 cites W1980614738 @default.
• W2984918847 cites W1982957249 @default.
• W2984918847 cites W1988861747 @default.
• W2984918847 cites W1996169421 @default.
• W2984918847 cites W2003019388 @default.
• W2984918847 cites W2004107498 @default.
• W2984918847 cites W2004607766 @default.
• W2984918847 cites W2005072972 @default.
• W2984918847 cites W2022186259 @default.
• W2984918847 cites W2038898868 @default.
• W2984918847 cites W2039777133 @default.
• W2984918847 cites W2043797361 @default.
• W2984918847 cites W2052398030 @default.
• W2984918847 cites W2055302806 @default.
• W2984918847 cites W2056883423 @default.
• W2984918847 cites W2065633945 @default.
• W2984918847 cites W2070024141 @default.
• W2984918847 cites W2090760490 @default.
• W2984918847 cites W2091315658 @default.
• W2984918847 cites W2110198088 @default.
• W2984918847 cites W2110849468 @default.
• W2984918847 cites W2114038592 @default.
• W2984918847 cites W2122472947 @default.
• W2984918847 cites W2125953041 @default.
• W2984918847 cites W2126912196 @default.
• W2984918847 cites W2130966741 @default.
• W2984918847 cites W2133784254 @default.
• W2984918847 cites W2134705330 @default.
• W2984918847 cites W2141789135 @default.
• W2984918847 cites W2154549928 @default.
• W2984918847 cites W2163382042 @default.
• W2984918847 cites W2164300345 @default.
• W2984918847 cites W2169984218 @default.
• W2984918847 cites W2171888478 @default.
• W2984918847 cites W2175652935 @default.
• W2984918847 cites W2333271618 @default.
• W2984918847 cites W2460819002 @default.
• W2984918847 cites W2519677077 @default.
• W2984918847 cites W2792791647 @default.
• W2984918847 cites W2887092190 @default.
• W2984918847 cites W2899225070 @default.
• W2984918847 cites W2906895010 @default.
• W2984918847 doi "https://doi.org/10.1038/s41598-019-53235-w" @default.
• W2984918847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6853930" @default.
• W2984918847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31723233" @default.
• W2984918847 hasPublicationYear "2019" @default.
• W2984918847 type Work @default.
• W2984918847 sameAs 2984918847 @default.
• W2984918847 citedByCount "6" @default.
• W2984918847 countsByYear W29849188472021 @default.
• W2984918847 countsByYear W29849188472022 @default.
• W2984918847 countsByYear W29849188472023 @default.
• W2984918847 crossrefType "journal-article" @default.
• W2984918847 hasAuthorship W2984918847A5011205540 @default.
• W2984918847 hasAuthorship W2984918847A5016640472 @default.
• W2984918847 hasAuthorship W2984918847A5030192831 @default.
• W2984918847 hasAuthorship W2984918847A5037467517 @default.
• W2984918847 hasAuthorship W2984918847A5047920066 @default.
• W2984918847 hasAuthorship W2984918847A5063660131 @default.
• W2984918847 hasBestOaLocation W29849188471 @default.
• W2984918847 hasConcept C105702510 @default.
• W2984918847 hasConcept C126322002 @default.
• W2984918847 hasConcept C151626666 @default.
• W2984918847 hasConcept C169760540 @default.
• W2984918847 hasConcept C185263204 @default.
• W2984918847 hasConcept C2776752467 @default.
• W2984918847 hasConcept C2778646069 @default.
• W2984918847 hasConcept C2779134260 @default.
• W2984918847 hasConcept C2780596555 @default.
• W2984918847 hasConcept C2780775167 @default.
• W2984918847 hasConcept C2781354215 @default.
• W2984918847 hasConcept C2781425072 @default.
• W2984918847 hasConcept C51738704 @default.
• W2984918847 hasConcept C71924100 @default.
• W2984918847 hasConcept C86803240 @default.
• W2984918847 hasConceptScore W2984918847C105702510 @default.
• W2984918847 hasConceptScore W2984918847C126322002 @default.
• W2984918847 hasConceptScore W2984918847C151626666 @default.
• W2984918847 hasConceptScore W2984918847C169760540 @default.
• W2984918847 hasConceptScore W2984918847C185263204 @default.
• W2984918847 hasConceptScore W2984918847C2776752467 @default.

• next