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- W2984918995 endingPage "580" @default.
- W2984918995 startingPage "580" @default.
- W2984918995 abstract "The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the examples of the successful use of multicistronic vectors have been described for the development of new methods of treatment of various human diseases, including cardiovascular, oncological, metabolic, autoimmune, and neurodegenerative disorders. The safety and effectiveness of the joint delivery of therapeutic genes in multicistronic vectors based on the internal ribosome entry site (IRES) and self-cleaving 2A peptides have been shown in both in vitro and in vivo experiments as well as in clinical trials. Co-expression of several genes in one vector has also been used to create animal models of various inherited diseases which are caused by mutations in several genes. Multicistronic vectors provide expression of all mutant genes, which allows the most complete mimicking disease pathogenesis. This review comprehensively discusses multicistronic vectors based on IRES nucleotide sequence and self-cleaving 2A peptides, including its features and possible application for the treatment and modeling of various human diseases." @default.
- W2984918995 created "2019-11-22" @default.
- W2984918995 creator A5031030770 @default.
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- W2984918995 creator A5065528355 @default.
- W2984918995 creator A5066414193 @default.
- W2984918995 date "2019-11-06" @default.
- W2984918995 modified "2023-10-17" @default.
- W2984918995 title "Production and Application of Multicistronic Constructs for Various Human Disease Therapies" @default.
- W2984918995 cites W1511863760 @default.
- W2984918995 cites W152388950 @default.
- W2984918995 cites W1551613500 @default.
- W2984918995 cites W1832822495 @default.
- W2984918995 cites W1856582230 @default.
- W2984918995 cites W1908675203 @default.
- W2984918995 cites W1964378686 @default.
- W2984918995 cites W1966974609 @default.
- W2984918995 cites W1969003683 @default.
- W2984918995 cites W1971146318 @default.
- W2984918995 cites W1972221671 @default.
- W2984918995 cites W1973049378 @default.
- W2984918995 cites W1977917700 @default.
- W2984918995 cites W1980586042 @default.
- W2984918995 cites W1982048287 @default.
- W2984918995 cites W1987647111 @default.
- W2984918995 cites W1988341070 @default.
- W2984918995 cites W1998349381 @default.
- W2984918995 cites W2000853857 @default.
- W2984918995 cites W2003754374 @default.
- W2984918995 cites W2005134836 @default.
- W2984918995 cites W2010180581 @default.
- W2984918995 cites W2010319708 @default.
- W2984918995 cites W2018162567 @default.
- W2984918995 cites W2023545713 @default.
- W2984918995 cites W2026638382 @default.
- W2984918995 cites W2026772281 @default.
- W2984918995 cites W2041122594 @default.
- W2984918995 cites W2042151937 @default.
- W2984918995 cites W2048731469 @default.
- W2984918995 cites W2052047971 @default.
- W2984918995 cites W2053762146 @default.
- W2984918995 cites W2058950912 @default.
- W2984918995 cites W2059126678 @default.
- W2984918995 cites W2064217264 @default.
- W2984918995 cites W2072408667 @default.
- W2984918995 cites W2078863695 @default.
- W2984918995 cites W2080576612 @default.
- W2984918995 cites W2081347853 @default.
- W2984918995 cites W2081705804 @default.
- W2984918995 cites W2087669477 @default.
- W2984918995 cites W2089934861 @default.
- W2984918995 cites W2092108158 @default.
- W2984918995 cites W2092504606 @default.
- W2984918995 cites W2093424805 @default.
- W2984918995 cites W2093956076 @default.
- W2984918995 cites W2098616624 @default.
- W2984918995 cites W2111166704 @default.
- W2984918995 cites W2116314384 @default.
- W2984918995 cites W2118098918 @default.
- W2984918995 cites W2122221211 @default.
- W2984918995 cites W2126115955 @default.
- W2984918995 cites W2128094872 @default.
- W2984918995 cites W2130275119 @default.
- W2984918995 cites W2148433210 @default.
- W2984918995 cites W2149108188 @default.
- W2984918995 cites W2165946984 @default.
- W2984918995 cites W2317365563 @default.
- W2984918995 cites W2324774087 @default.
- W2984918995 cites W2325350956 @default.
- W2984918995 cites W2326896373 @default.
- W2984918995 cites W2412094269 @default.
- W2984918995 cites W2460561538 @default.
- W2984918995 cites W2461423397 @default.
- W2984918995 cites W2497952843 @default.
- W2984918995 cites W2556164933 @default.
- W2984918995 cites W2561618083 @default.
- W2984918995 cites W2563948931 @default.
- W2984918995 cites W2564495924 @default.
- W2984918995 cites W2575946871 @default.
- W2984918995 cites W2590198016 @default.
- W2984918995 cites W2598775808 @default.
- W2984918995 cites W2615853094 @default.
- W2984918995 cites W2621482563 @default.
- W2984918995 cites W2762570693 @default.
- W2984918995 cites W2762633367 @default.
- W2984918995 cites W2769541324 @default.
- W2984918995 cites W2773964739 @default.
- W2984918995 cites W2781189017 @default.
- W2984918995 cites W2783040988 @default.
- W2984918995 cites W2793221955 @default.
- W2984918995 cites W2796322027 @default.
- W2984918995 cites W2802183733 @default.
- W2984918995 cites W2804535713 @default.
- W2984918995 cites W2884292353 @default.