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• W2984991656 startingPage "83" @default.
• W2984991656 abstract "Abstract G protein‐coupled receptors (GPCRs) are core switches connecting excellular survival or death signals with cellular signaling pathways in a context‐dependent manner. Opsin 3 (OPN3) belongs to the GPCR superfamily. However, whether OPN3 can control the survival or death of human melanocytes is not known. Here, we try to investigate the inherent function of OPN3 on the survival of melanocytes. Our results demonstrate that OPN3 knockdown by RNAi‐OPN3 in human epidermal melanocytes leads to cell apoptosis. The downregulation of OPN3 markedly reduces intracellular calcium levels and decreases phosphorylation of BAD. Attenuated BAD phosphorylation and elevated BAD protein level alter mitochondria membrane permeability, which trigger activation of BAX and inhibition of BCL‐2 and raf‐1. Activated BAX results in the release of cytochrome c and the loss of mitochondrial membrane potential. Cytochrome c complexes associate with caspase 9, forming a postmitochondrial apoptosome that activate effector caspases including caspase 3 and caspase 7. The release of apoptotic molecules eventually promotes the occurrence of apoptosis. In conclusion, we hereby are the first to prove that OPN3 is a key signal responsible for cell survival through a calcium‐dependent G protein‐coupled signaling and mitochondrial pathway." @default.
• W2984991656 created "2019-11-22" @default.
• W2984991656 creator A5027972871 @default.
• W2984991656 creator A5041535292 @default.
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• W2984991656 date "2020-01-01" @default.
• W2984991656 modified "2023-10-14" @default.
• W2984991656 title "Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes <i>via </i>Mitochondrial Pathway" @default.
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• W2984991656 doi "https://doi.org/10.1111/php.13178" @default.
• W2984991656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7004086" @default.
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• W2984991656 hasPublicationYear "2020" @default.
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