Matches in SemOpenAlex for { <https://semopenalex.org/work/W2984996854> ?p ?o ?g. }
- W2984996854 abstract "Abstract Orf is a highly contagious zoonotic disease of small ruminants caused by Parapoxvirus. Kisspeptin, encoded by the KISS1 gene with its cognate receptor GPR-54 is recognized as an upstream orchestrator in the hypothalamic-pituitary-gonadal axis. This study was designed to construct a DNA vaccine that produces a fused peptide composed of a major immunodominant protein of the orf virus (B2L) and kisspeptin-54, a neuropeptide with recognized roles in mammalian reproductive biology. The administration of this recombinant vaccine is shown to produce a significant antibody and cell-mediated immune response directed against B2L compared to the control group ( p < 0.05). Furthermore, we found that rats inoculated with PBK-asd vaccine up-regulated antigen-mediated splenocyte proliferation and significantly raised antigen-specific tumor necrosis factor-alpha (TNFα-), interferon-gamma (IFN-ϒ) and interleukin (IL-2) compared to the control group ( p < 0.05). This recombinant vaccine also stimulated antibody responses to kisspeptin and decreased serum luteinizing hormone and testosterone levels. Moreover, the current recombinant vaccine caused testicular atrophy and arrested spermatogenesis. It is concluded that this recombinant B2L and Kisspeptin-54 vaccine could be a promising approach for construction of bivalent orf virus and immunocastration vaccine. Furthermore, we concluded that the orf virus envelope protein (B2L) could be used as an immunomodulator for kisspeptin-54 to produce a strong antibody response." @default.
- W2984996854 created "2019-11-22" @default.
- W2984996854 creator A5000786460 @default.
- W2984996854 creator A5010543839 @default.
- W2984996854 creator A5036838178 @default.
- W2984996854 creator A5040462999 @default.
- W2984996854 creator A5072744166 @default.
- W2984996854 creator A5081267531 @default.
- W2984996854 creator A5082147683 @default.
- W2984996854 creator A5084497344 @default.
- W2984996854 creator A5087300875 @default.
- W2984996854 date "2019-11-07" @default.
- W2984996854 modified "2023-09-30" @default.
- W2984996854 title "Recombinant B2L and Kisspeptin-54 DNA Vaccine Induces Immunity Against Orf Virus and Inhibits Spermatogenesis In Rats" @default.
- W2984996854 cites W1965168935 @default.
- W2984996854 cites W1970097921 @default.
- W2984996854 cites W1986474989 @default.
- W2984996854 cites W2002124880 @default.
- W2984996854 cites W2014895004 @default.
- W2984996854 cites W2035199058 @default.
- W2984996854 cites W2035723545 @default.
- W2984996854 cites W2042707654 @default.
- W2984996854 cites W2049637117 @default.
- W2984996854 cites W2051125955 @default.
- W2984996854 cites W2058721060 @default.
- W2984996854 cites W2064610874 @default.
- W2984996854 cites W2067130406 @default.
- W2984996854 cites W2081301292 @default.
- W2984996854 cites W2091846368 @default.
- W2984996854 cites W2092300447 @default.
- W2984996854 cites W2098037167 @default.
- W2984996854 cites W2120568375 @default.
- W2984996854 cites W2121986949 @default.
- W2984996854 cites W2140052074 @default.
- W2984996854 cites W2140561350 @default.
- W2984996854 cites W2141094288 @default.
- W2984996854 cites W2195338808 @default.
- W2984996854 cites W2316870491 @default.
- W2984996854 cites W2562048827 @default.
- W2984996854 cites W2604727013 @default.
- W2984996854 cites W2607981137 @default.
- W2984996854 cites W2765463444 @default.
- W2984996854 cites W2793471912 @default.
- W2984996854 cites W2794199458 @default.
- W2984996854 cites W2899878653 @default.
- W2984996854 doi "https://doi.org/10.1038/s41598-019-52744-y" @default.
- W2984996854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6838309" @default.
- W2984996854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31700161" @default.
- W2984996854 hasPublicationYear "2019" @default.
- W2984996854 type Work @default.
- W2984996854 sameAs 2984996854 @default.
- W2984996854 citedByCount "9" @default.
- W2984996854 countsByYear W29849968542020 @default.
- W2984996854 countsByYear W29849968542021 @default.
- W2984996854 countsByYear W29849968542022 @default.
- W2984996854 countsByYear W29849968542023 @default.
- W2984996854 crossrefType "journal-article" @default.
- W2984996854 hasAuthorship W2984996854A5000786460 @default.
- W2984996854 hasAuthorship W2984996854A5010543839 @default.
- W2984996854 hasAuthorship W2984996854A5036838178 @default.
- W2984996854 hasAuthorship W2984996854A5040462999 @default.
- W2984996854 hasAuthorship W2984996854A5072744166 @default.
- W2984996854 hasAuthorship W2984996854A5081267531 @default.
- W2984996854 hasAuthorship W2984996854A5082147683 @default.
- W2984996854 hasAuthorship W2984996854A5084497344 @default.
- W2984996854 hasAuthorship W2984996854A5087300875 @default.
- W2984996854 hasBestOaLocation W29849968541 @default.
- W2984996854 hasConcept C104317684 @default.
- W2984996854 hasConcept C134018914 @default.
- W2984996854 hasConcept C147483822 @default.
- W2984996854 hasConcept C159047783 @default.
- W2984996854 hasConcept C159654299 @default.
- W2984996854 hasConcept C167508917 @default.
- W2984996854 hasConcept C203014093 @default.
- W2984996854 hasConcept C2522874641 @default.
- W2984996854 hasConcept C2776808119 @default.
- W2984996854 hasConcept C2780801004 @default.
- W2984996854 hasConcept C40767141 @default.
- W2984996854 hasConcept C55493867 @default.
- W2984996854 hasConcept C71315377 @default.
- W2984996854 hasConcept C86803240 @default.
- W2984996854 hasConcept C8891405 @default.
- W2984996854 hasConceptScore W2984996854C104317684 @default.
- W2984996854 hasConceptScore W2984996854C134018914 @default.
- W2984996854 hasConceptScore W2984996854C147483822 @default.
- W2984996854 hasConceptScore W2984996854C159047783 @default.
- W2984996854 hasConceptScore W2984996854C159654299 @default.
- W2984996854 hasConceptScore W2984996854C167508917 @default.
- W2984996854 hasConceptScore W2984996854C203014093 @default.
- W2984996854 hasConceptScore W2984996854C2522874641 @default.
- W2984996854 hasConceptScore W2984996854C2776808119 @default.
- W2984996854 hasConceptScore W2984996854C2780801004 @default.
- W2984996854 hasConceptScore W2984996854C40767141 @default.
- W2984996854 hasConceptScore W2984996854C55493867 @default.
- W2984996854 hasConceptScore W2984996854C71315377 @default.
- W2984996854 hasConceptScore W2984996854C86803240 @default.
- W2984996854 hasConceptScore W2984996854C8891405 @default.
- W2984996854 hasIssue "1" @default.
- W2984996854 hasLocation W29849968541 @default.
- W2984996854 hasLocation W29849968542 @default.