Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985047872> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2985047872 abstract "The importance of genome organization at the supranucleosomal scale in the control of gene expression is increasingly recognized today. In mammals, Topologically Associating Domains (TADs) and the active / inactive chromosomal compartments are two of the main nuclear structures that contribute to this organization level. However, recent works reviewed here indicate that, at specific loci, chromatin interactions with nuclear bodies could also be crucial to regulate genome functions, in particular transcription. They moreover suggest that these nuclear bodies are membrane-less organelles dynamically self-assembled and disassembled through mechanisms of phase separation. We have recently developed a novel genome-wide experimental method, High-salt Recovered Sequences sequencing (HRS-seq), which allows the identification of chromatin regions associated with large ribonucleoprotein (RNP) complexes and nuclear bodies. We argue that the physical nature of such RNP complexes and nuclear bodies appears to be central in their ability to promote efficient interactions between distant genomic regions. The development of novel experimental approaches, including our HRS-seq method, is opening new avenues to understand how self-assembly of phase separated nuclear bodies possibly contributes to mammalian genome organization and gene expression." @default.
- W2985047872 created "2019-11-22" @default.
- W2985047872 creator A5007093224 @default.
- W2985047872 creator A5039749824 @default.
- W2985047872 creator A5048093443 @default.
- W2985047872 creator A5068924391 @default.
- W2985047872 date "2019-12-04" @default.
- W2985047872 modified "2023-10-17" @default.
- W2985047872 title "Exploring Mammalian Genome within Phase-Separated Nuclear Bodies: Implications for the Regulation of Gene Expression" @default.
- W2985047872 doi "https://doi.org/10.20944/preprints201911.0076.v2" @default.
- W2985047872 hasPublicationYear "2019" @default.
- W2985047872 type Work @default.
- W2985047872 sameAs 2985047872 @default.
- W2985047872 citedByCount "0" @default.
- W2985047872 crossrefType "posted-content" @default.
- W2985047872 hasAuthorship W2985047872A5007093224 @default.
- W2985047872 hasAuthorship W2985047872A5039749824 @default.
- W2985047872 hasAuthorship W2985047872A5048093443 @default.
- W2985047872 hasAuthorship W2985047872A5068924391 @default.
- W2985047872 hasBestOaLocation W29850478721 @default.
- W2985047872 hasConcept C104317684 @default.
- W2985047872 hasConcept C141231307 @default.
- W2985047872 hasConcept C150194340 @default.
- W2985047872 hasConcept C20750100 @default.
- W2985047872 hasConcept C22322919 @default.
- W2985047872 hasConcept C54355233 @default.
- W2985047872 hasConcept C67705224 @default.
- W2985047872 hasConcept C70721500 @default.
- W2985047872 hasConcept C75934600 @default.
- W2985047872 hasConcept C83640560 @default.
- W2985047872 hasConcept C86803240 @default.
- W2985047872 hasConceptScore W2985047872C104317684 @default.
- W2985047872 hasConceptScore W2985047872C141231307 @default.
- W2985047872 hasConceptScore W2985047872C150194340 @default.
- W2985047872 hasConceptScore W2985047872C20750100 @default.
- W2985047872 hasConceptScore W2985047872C22322919 @default.
- W2985047872 hasConceptScore W2985047872C54355233 @default.
- W2985047872 hasConceptScore W2985047872C67705224 @default.
- W2985047872 hasConceptScore W2985047872C70721500 @default.
- W2985047872 hasConceptScore W2985047872C75934600 @default.
- W2985047872 hasConceptScore W2985047872C83640560 @default.
- W2985047872 hasConceptScore W2985047872C86803240 @default.
- W2985047872 hasLocation W29850478721 @default.
- W2985047872 hasLocation W29850478722 @default.
- W2985047872 hasOpenAccess W2985047872 @default.
- W2985047872 hasPrimaryLocation W29850478721 @default.
- W2985047872 hasRelatedWork W14098964 @default.
- W2985047872 hasRelatedWork W15727706 @default.
- W2985047872 hasRelatedWork W16304471 @default.
- W2985047872 hasRelatedWork W17129757 @default.
- W2985047872 hasRelatedWork W18597697 @default.
- W2985047872 hasRelatedWork W18869134 @default.
- W2985047872 hasRelatedWork W30154354 @default.
- W2985047872 hasRelatedWork W34362802 @default.
- W2985047872 hasRelatedWork W35706479 @default.
- W2985047872 hasRelatedWork W4134988 @default.
- W2985047872 isParatext "false" @default.
- W2985047872 isRetracted "false" @default.
- W2985047872 magId "2985047872" @default.
- W2985047872 workType "article" @default.