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- W2985076304 abstract "In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing." @default.
- W2985076304 created "2019-11-22" @default.
- W2985076304 creator A5010415839 @default.
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- W2985076304 date "2019-11-14" @default.
- W2985076304 modified "2023-10-15" @default.
- W2985076304 title "In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications" @default.
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- W2985076304 doi "https://doi.org/10.3390/jfb10040050" @default.
- W2985076304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6963958" @default.
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- W2985076304 hasPublicationYear "2019" @default.
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