Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985079001> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2985079001 endingPage "A24" @default.
- W2985079001 startingPage "A24.1" @default.
- W2985079001 abstract "Introduction Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder presenting with behavioural or speech problems. Identification of the underlying molecular abnormality during life remains elusive, and there are no reliable biomarkers of TDP-43 proteinopathies. Proteomic analysis of the TDP-43 proteinopathies provides a unique opportunity to better understand the disease-associated pathways and determine surrogate biomarkers of TDP-43 pathology. Materials and methods We set out to investigate the proteomic profile of TDP-43 proteinopathies using label-free quantitative mass spectrometry. 15 cases were selected: 9 had histologically confirmed TDP-43 inclusions as their primary pathology, 3 had Alzheimer’s disease (AD) pathology (without TDP-43 disease) and 3 were healthy controls. Three regions from each case were examined: frontal lobe, temporal lobe and hippocampus. Samples were pooled according to pathological group and brain region before mass spectrometric analysis (Synapt G2-Si nanoAcquity LC system). Results 21 proteins were significantly upregulated in TDP-43 proteinopathies compared with AD and 30 proteins were downregulated. The majority of proteins identified are implicated in ribosomal function, RNA transportation and mitochondrial matrix enzymatic function. Whilst, several proteins identified have already been shown to be implicated pathophysiologically in FTD/ALS the majority have not, providing a new insight into disease pathogenesis. Discussion Preliminary proteomic analyses of brain tissue from TDP-43 proteinopathies has identified a number of differentially expressed proteins, providing a starting point for new biomarker development to distinguish different pathological subtypes of FTD during life." @default.
- W2985079001 created "2019-11-22" @default.
- W2985079001 creator A5002116784 @default.
- W2985079001 creator A5043816912 @default.
- W2985079001 creator A5044815748 @default.
- W2985079001 creator A5045744302 @default.
- W2985079001 creator A5050946548 @default.
- W2985079001 creator A5070348432 @default.
- W2985079001 date "2019-11-14" @default.
- W2985079001 modified "2023-09-25" @default.
- W2985079001 title "057 Proteomic analysis of TDP-43 pathology in frontotemporal dementia" @default.
- W2985079001 doi "https://doi.org/10.1136/jnnp-2019-abn-2.78" @default.
- W2985079001 hasPublicationYear "2019" @default.
- W2985079001 type Work @default.
- W2985079001 sameAs 2985079001 @default.
- W2985079001 citedByCount "0" @default.
- W2985079001 crossrefType "journal-article" @default.
- W2985079001 hasAuthorship W2985079001A5002116784 @default.
- W2985079001 hasAuthorship W2985079001A5043816912 @default.
- W2985079001 hasAuthorship W2985079001A5044815748 @default.
- W2985079001 hasAuthorship W2985079001A5045744302 @default.
- W2985079001 hasAuthorship W2985079001A5050946548 @default.
- W2985079001 hasAuthorship W2985079001A5070348432 @default.
- W2985079001 hasConcept C104317684 @default.
- W2985079001 hasConcept C142724271 @default.
- W2985079001 hasConcept C169760540 @default.
- W2985079001 hasConcept C207886595 @default.
- W2985079001 hasConcept C2776939681 @default.
- W2985079001 hasConcept C2778641062 @default.
- W2985079001 hasConcept C2779134260 @default.
- W2985079001 hasConcept C2779483572 @default.
- W2985079001 hasConcept C2781197716 @default.
- W2985079001 hasConcept C46111723 @default.
- W2985079001 hasConcept C502032728 @default.
- W2985079001 hasConcept C55493867 @default.
- W2985079001 hasConcept C71924100 @default.
- W2985079001 hasConcept C74092355 @default.
- W2985079001 hasConcept C86803240 @default.
- W2985079001 hasConceptScore W2985079001C104317684 @default.
- W2985079001 hasConceptScore W2985079001C142724271 @default.
- W2985079001 hasConceptScore W2985079001C169760540 @default.
- W2985079001 hasConceptScore W2985079001C207886595 @default.
- W2985079001 hasConceptScore W2985079001C2776939681 @default.
- W2985079001 hasConceptScore W2985079001C2778641062 @default.
- W2985079001 hasConceptScore W2985079001C2779134260 @default.
- W2985079001 hasConceptScore W2985079001C2779483572 @default.
- W2985079001 hasConceptScore W2985079001C2781197716 @default.
- W2985079001 hasConceptScore W2985079001C46111723 @default.
- W2985079001 hasConceptScore W2985079001C502032728 @default.
- W2985079001 hasConceptScore W2985079001C55493867 @default.
- W2985079001 hasConceptScore W2985079001C71924100 @default.
- W2985079001 hasConceptScore W2985079001C74092355 @default.
- W2985079001 hasConceptScore W2985079001C86803240 @default.
- W2985079001 hasIssue "12" @default.
- W2985079001 hasLocation W29850790011 @default.
- W2985079001 hasOpenAccess W2985079001 @default.
- W2985079001 hasPrimaryLocation W29850790011 @default.
- W2985079001 hasRelatedWork W1987489496 @default.
- W2985079001 hasRelatedWork W1997528168 @default.
- W2985079001 hasRelatedWork W1997809912 @default.
- W2985079001 hasRelatedWork W2003488445 @default.
- W2985079001 hasRelatedWork W2066700083 @default.
- W2985079001 hasRelatedWork W206978487 @default.
- W2985079001 hasRelatedWork W2093276554 @default.
- W2985079001 hasRelatedWork W2093334504 @default.
- W2985079001 hasRelatedWork W2102849144 @default.
- W2985079001 hasRelatedWork W2110074226 @default.
- W2985079001 hasRelatedWork W2125931517 @default.
- W2985079001 hasRelatedWork W2406964020 @default.
- W2985079001 hasRelatedWork W2588245933 @default.
- W2985079001 hasRelatedWork W2912060415 @default.
- W2985079001 hasRelatedWork W2990899750 @default.
- W2985079001 hasRelatedWork W3092714021 @default.
- W2985079001 hasRelatedWork W3112101826 @default.
- W2985079001 hasRelatedWork W3113198890 @default.
- W2985079001 hasRelatedWork W3163732962 @default.
- W2985079001 hasRelatedWork W2427760629 @default.
- W2985079001 hasVolume "90" @default.
- W2985079001 isParatext "false" @default.
- W2985079001 isRetracted "false" @default.
- W2985079001 magId "2985079001" @default.
- W2985079001 workType "article" @default.