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- W2985139852 abstract "Aims Several interventions have been implemented to prevent the development of gestational diabetes mellitus (GDM) in obese pregnant women, including physical exercise programs, and administration of metformin, vitamin D and probiotics. The aim of this network meta‐analysis was to compare the efficiency of these interventions and identify the optimal. Materials A network meta-analysis of randomized trials was performed comparing the different interventions for the development of GDM in overweight or obese women, either to each other or placebo/no intervention. A search was conducted in four electronic databases and grey literature sources. The primary outcome was the development of GDM; secondary outcomes were other complications of pregnancy. Results The meta-analysis included 23 studies (4237 participants). None of the interventions was superior compared with placebo/no intervention for the prevention of GDM. Metformin and physical exercise were superior to placebo/no intervention for gestational weight gain (MD −1.21, 95% CI −2.14 to −0.28 and MD −0.96, 95% CI −1.69 to −0.22, respectively). Metformin was superior to placebo/no intervention for caesarean sections and admission to NICU. Conclusions Interventions aiming to prevent the development of GDM in overweight/obese women are not effective, when applied during pregnancy." @default.
- W2985139852 created "2019-11-22" @default.
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- W2985139852 date "2019-12-01" @default.
- W2985139852 modified "2023-09-27" @default.
- W2985139852 title "Prevention of gestational diabetes mellitus in overweight or obese pregnant women: A network meta-analysis" @default.
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- W2985139852 doi "https://doi.org/10.1016/j.diabres.2019.107924" @default.
- W2985139852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31738997" @default.
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