FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985146793> ?p ?o ?g. }

• W2985146793 endingPage "23517" @default.
• W2985146793 startingPage "23512" @default.
• W2985146793 abstract "Pat1 is a hub for mRNA metabolism, acting in pre-mRNA splicing, translation repression, and mRNA decay. A critical step in all 5′-3′ mRNA decay pathways is removal of the 5′ cap structure, which precedes and permits digestion of the RNA body by conserved exonucleases. During bulk 5′-3′ decay, the Pat1/Lsm1-7 complex engages mRNA at the 3′ end and promotes hydrolysis of the cap structure by Dcp1/Dcp2 at the 5′ end through an unknown mechanism. We reconstitute Pat1 with 5′ and 3′ decay factors and show how it activates multiple steps in late mRNA decay. First, we find that Pat1 stabilizes binding of the Lsm1-7 complex to RNA using two conserved short-linear interaction motifs. Second, Pat1 directly activates decapping by binding elements in the disordered C-terminal extension of Dcp2, alleviating autoinhibition and promoting substrate binding. Our results uncover the molecular mechanism of how separate domains of Pat1 coordinate the assembly and activation of a decapping messenger ribonucleoprotein (mRNP) that promotes 5′-3′ mRNA degradation." @default.
• W2985146793 created "2019-11-22" @default.
• W2985146793 creator A5007999152 @default.
• W2985146793 creator A5040138828 @default.
• W2985146793 creator A5083687986 @default.
• W2985146793 date "2019-11-05" @default.
• W2985146793 modified "2023-10-01" @default.
• W2985146793 title "Pat1 activates late steps in mRNA decay by multiple mechanisms" @default.
• W2985146793 cites W1521868395 @default.
• W2985146793 cites W1744683414 @default.
• W2985146793 cites W1881881808 @default.
• W2985146793 cites W1963577021 @default.
• W2985146793 cites W1966250642 @default.
• W2985146793 cites W1970626969 @default.
• W2985146793 cites W1971644927 @default.
• W2985146793 cites W1974365072 @default.
• W2985146793 cites W1976527580 @default.
• W2985146793 cites W1985057553 @default.
• W2985146793 cites W1990214042 @default.
• W2985146793 cites W2010081999 @default.
• W2985146793 cites W2031345354 @default.
• W2985146793 cites W2031707270 @default.
• W2985146793 cites W2035398832 @default.
• W2985146793 cites W2046181612 @default.
• W2985146793 cites W2057726003 @default.
• W2985146793 cites W2068778722 @default.
• W2985146793 cites W2078319586 @default.
• W2985146793 cites W2088399865 @default.
• W2985146793 cites W2105992602 @default.
• W2985146793 cites W2117764830 @default.
• W2985146793 cites W2124223800 @default.
• W2985146793 cites W2133929311 @default.
• W2985146793 cites W2133968430 @default.
• W2985146793 cites W2135419864 @default.
• W2985146793 cites W2136987752 @default.
• W2985146793 cites W2142571092 @default.
• W2985146793 cites W2143205681 @default.
• W2985146793 cites W2150104695 @default.
• W2985146793 cites W2153114644 @default.
• W2985146793 cites W2154950250 @default.
• W2985146793 cites W2159682640 @default.
• W2985146793 cites W2167144689 @default.
• W2985146793 cites W2329808975 @default.
• W2985146793 cites W2475355234 @default.
• W2985146793 cites W2563743843 @default.
• W2985146793 cites W2664577579 @default.
• W2985146793 cites W2759609596 @default.
• W2985146793 cites W2766233020 @default.
• W2985146793 cites W2784370070 @default.
• W2985146793 cites W2792145634 @default.
• W2985146793 cites W2950116361 @default.
• W2985146793 cites W2950923159 @default.
• W2985146793 doi "https://doi.org/10.1073/pnas.1905455116" @default.
• W2985146793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6876151" @default.
• W2985146793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31690658" @default.
• W2985146793 hasPublicationYear "2019" @default.
• W2985146793 type Work @default.
• W2985146793 sameAs 2985146793 @default.
• W2985146793 citedByCount "20" @default.
• W2985146793 countsByYear W29851467932020 @default.
• W2985146793 countsByYear W29851467932021 @default.
• W2985146793 countsByYear W29851467932022 @default.
• W2985146793 countsByYear W29851467932023 @default.
• W2985146793 crossrefType "journal-article" @default.
• W2985146793 hasAuthorship W2985146793A5007999152 @default.
• W2985146793 hasAuthorship W2985146793A5040138828 @default.
• W2985146793 hasAuthorship W2985146793A5083687986 @default.
• W2985146793 hasBestOaLocation W29851467931 @default.
• W2985146793 hasConcept C104317684 @default.
• W2985146793 hasConcept C105580179 @default.
• W2985146793 hasConcept C128943096 @default.
• W2985146793 hasConcept C149364088 @default.
• W2985146793 hasConcept C153911025 @default.
• W2985146793 hasConcept C162419368 @default.
• W2985146793 hasConcept C185592680 @default.
• W2985146793 hasConcept C2991743866 @default.
• W2985146793 hasConcept C41282012 @default.
• W2985146793 hasConcept C54458228 @default.
• W2985146793 hasConcept C55493867 @default.
• W2985146793 hasConcept C67705224 @default.
• W2985146793 hasConcept C70219777 @default.
• W2985146793 hasConcept C75449159 @default.
• W2985146793 hasConcept C75934600 @default.
• W2985146793 hasConcept C86803240 @default.
• W2985146793 hasConcept C95444343 @default.
• W2985146793 hasConceptScore W2985146793C104317684 @default.
• W2985146793 hasConceptScore W2985146793C105580179 @default.
• W2985146793 hasConceptScore W2985146793C128943096 @default.
• W2985146793 hasConceptScore W2985146793C149364088 @default.
• W2985146793 hasConceptScore W2985146793C153911025 @default.
• W2985146793 hasConceptScore W2985146793C162419368 @default.
• W2985146793 hasConceptScore W2985146793C185592680 @default.
• W2985146793 hasConceptScore W2985146793C2991743866 @default.
• W2985146793 hasConceptScore W2985146793C41282012 @default.
• W2985146793 hasConceptScore W2985146793C54458228 @default.
• W2985146793 hasConceptScore W2985146793C55493867 @default.
• W2985146793 hasConceptScore W2985146793C67705224 @default.
• W2985146793 hasConceptScore W2985146793C70219777 @default.

• next