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- W2985192224 endingPage "1706.e4" @default.
- W2985192224 startingPage "1690" @default.
- W2985192224 abstract "Changes in the endothelium of the cerebral vasculature can contribute to inflammatory, thrombotic, and malignant disorders. The importance of defining cell-type-specific genes and their modification in disease is increasingly recognized. Here, we develop a bioinformatics-based approach to identify normal brain cell-enriched genes, using bulk RNA sequencing (RNA-seq) data from 238 normal human cortex samples from 2 independent cohorts. We compare endothelial cell-enriched gene profiles with astrocyte, oligodendrocyte, neuron, and microglial cell profiles. Endothelial changes in malignant disease are explored using RNA-seq data from 516 lower-grade gliomas and 401 glioblastomas. Lower-grade gliomas appear to be an “endothelial intermediate” between normal brain and glioblastoma. We apply our method for the prediction of glioblastoma-specific endothelial biomarkers, providing potential diagnostic or therapeutic targets. In summary, we provide a roadmap of endothelial cell identity in normal and malignant brain, using a method developed to resolve bulk RNA-seq into constituent cell-type-enriched profiles." @default.
- W2985192224 created "2019-11-22" @default.
- W2985192224 creator A5011635059 @default.
- W2985192224 creator A5041800520 @default.
- W2985192224 creator A5055072095 @default.
- W2985192224 creator A5060241561 @default.
- W2985192224 creator A5080838497 @default.
- W2985192224 creator A5084280756 @default.
- W2985192224 date "2019-11-01" @default.
- W2985192224 modified "2023-10-16" @default.
- W2985192224 title "A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes" @default.
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