FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985236709> ?p ?o ?g. }

• W2985236709 abstract "Pancreatic duct adenocarcinoma (PDAC) is a highly malignant type of cancer with a low five-year survival rate. Gene alterations are crucial to the molecular pathogenesis of PDAC. Therefore, the present study analyzed gene expression profiles to reveal genes involved in the tumorigenesis of PDAC. A total of eight gene expression profiles (GSE15471, GSE16515, GSE41368, GSE62165, GSE62452, GSE71729, GSE71989 and GSE91035) and a PDAC dataset were acquired from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database, respectively. Differentially expressed genes (DEGs) were screened using functional annotation, Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and protein-protein interaction (PPI) network construction. A Cox proportional hazards model was then constructed and used to analyze the data. A total of 136 DEGs (67 up- and 69 downregulated genes) were identified between PDAC tissues and normal tissues. The 'extracellular matrix-related' genes were the most enriched in the GO term analysis. 'Pancreatic secretion', 'phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-Akt) signaling pathway', 'protein digestion and absorption' and 'ECM-receptor interaction' were the most enriched categories in KEGG pathway analysis. Following PPI network construction, the 10 most significant genes [albumin, epidermal growth factor, matrix metalloproteinase (MMP) 9, epidermal growth factor receptor, fibronectin 1, MMP1, plasminogen activator inhibitor-1, tissue inhibitor of metalloproteinase 1, plasminogen activator urokinase (PLAU) and PLAU receptor) exhibiting a high degree of connectivity, were identified as the hub genes likely to be associated with the pathogenesis of PDAC. In addition, a prognostic predictive system for PDAC, composed of five genes (laminin subunit γ 2, laminin subunit β 3, serpin family B member 5, amphiregulin and secreted frizzled related protein 4), was constructed. This was validated in the GSE62452 dataset (using 66 PDAC samples with outcome data) and TCGA PDAC dataset (using 146 PDAC samples with outcome data). In conclusion, the present study revealed potential hub genes involved in PDAC progression, providing directive significance for individualized clinical decision-making and molecular-targeting therapy in patients with PDAC." @default.
• W2985236709 created "2019-11-22" @default.
• W2985236709 creator A5016192309 @default.
• W2985236709 creator A5029400417 @default.
• W2985236709 creator A5031969365 @default.
• W2985236709 creator A5034442821 @default.
• W2985236709 creator A5050459862 @default.
• W2985236709 creator A5087837180 @default.
• W2985236709 creator A5089559870 @default.
• W2985236709 date "2019-11-04" @default.
• W2985236709 modified "2023-10-16" @default.
• W2985236709 title "Identification of potential hub genes associated with the pathogenesis and prognosis of pancreatic duct adenocarcinoma using bioinformatics meta‑analysis of multi‑platform datasets" @default.
• W2985236709 cites W1270834676 @default.
• W2985236709 cites W1417555467 @default.
• W2985236709 cites W1497915798 @default.
• W2985236709 cites W1687788096 @default.
• W2985236709 cites W1964350418 @default.
• W2985236709 cites W1965850768 @default.
• W2985236709 cites W1979538859 @default.
• W2985236709 cites W1985538444 @default.
• W2985236709 cites W1986654967 @default.
• W2985236709 cites W1988886103 @default.
• W2985236709 cites W1996667997 @default.
• W2985236709 cites W1998691880 @default.
• W2985236709 cites W1999873374 @default.
• W2985236709 cites W2007099293 @default.
• W2985236709 cites W2007649418 @default.
• W2985236709 cites W2010304520 @default.
• W2985236709 cites W2014477053 @default.
• W2985236709 cites W2017349266 @default.
• W2985236709 cites W2027678100 @default.
• W2985236709 cites W2032066777 @default.
• W2985236709 cites W2037107824 @default.
• W2985236709 cites W2037305898 @default.
• W2985236709 cites W2040935952 @default.
• W2985236709 cites W2043796673 @default.
• W2985236709 cites W2052705131 @default.
• W2985236709 cites W2066949228 @default.
• W2985236709 cites W2074654885 @default.
• W2985236709 cites W2099055911 @default.
• W2985236709 cites W2100427896 @default.
• W2985236709 cites W2107584699 @default.
• W2985236709 cites W2109995938 @default.
• W2985236709 cites W2115124692 @default.
• W2985236709 cites W2116586864 @default.
• W2985236709 cites W2118633267 @default.
• W2985236709 cites W2119792393 @default.
• W2985236709 cites W2123206362 @default.
• W2985236709 cites W2126889260 @default.
• W2985236709 cites W2146511318 @default.
• W2985236709 cites W2148016640 @default.
• W2985236709 cites W2149449623 @default.
• W2985236709 cites W2158734599 @default.
• W2985236709 cites W2194697488 @default.
• W2985236709 cites W2220944543 @default.
• W2985236709 cites W2270009322 @default.
• W2985236709 cites W2336715782 @default.
• W2985236709 cites W2408666766 @default.
• W2985236709 cites W2462520477 @default.
• W2985236709 cites W2474644024 @default.
• W2985236709 cites W2476542314 @default.
• W2985236709 cites W2504977350 @default.
• W2985236709 cites W2510654794 @default.
• W2985236709 cites W2514712994 @default.
• W2985236709 cites W2584623346 @default.
• W2985236709 cites W2600950206 @default.
• W2985236709 cites W2615224981 @default.
• W2985236709 cites W2749287856 @default.
• W2985236709 cites W2783237763 @default.
• W2985236709 cites W2783407769 @default.
• W2985236709 cites W2793465679 @default.
• W2985236709 cites W2800199725 @default.
• W2985236709 cites W2805695913 @default.
• W2985236709 cites W2806546430 @default.
• W2985236709 cites W286742153 @default.
• W2985236709 cites W2889646458 @default.
• W2985236709 cites W2890044737 @default.
• W2985236709 cites W2895109146 @default.
• W2985236709 cites W2915984865 @default.
• W2985236709 cites W2974104874 @default.
• W2985236709 cites W4244578979 @default.
• W2985236709 cites W1984967097 @default.
• W2985236709 doi "https://doi.org/10.3892/ol.2019.11042" @default.
• W2985236709 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6876339" @default.
• W2985236709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31807183" @default.
• W2985236709 hasPublicationYear "2019" @default.
• W2985236709 type Work @default.
• W2985236709 sameAs 2985236709 @default.
• W2985236709 citedByCount "7" @default.
• W2985236709 countsByYear W29852367092020 @default.
• W2985236709 countsByYear W29852367092021 @default.
• W2985236709 countsByYear W29852367092022 @default.
• W2985236709 crossrefType "journal-article" @default.
• W2985236709 hasAuthorship W2985236709A5016192309 @default.
• W2985236709 hasAuthorship W2985236709A5029400417 @default.
• W2985236709 hasAuthorship W2985236709A5031969365 @default.
• W2985236709 hasAuthorship W2985236709A5034442821 @default.
• W2985236709 hasAuthorship W2985236709A5050459862 @default.
• W2985236709 hasAuthorship W2985236709A5087837180 @default.
• W2985236709 hasAuthorship W2985236709A5089559870 @default.

• next