Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985242335> ?p ?o ?g. }
- W2985242335 endingPage "130" @default.
- W2985242335 startingPage "116" @default.
- W2985242335 abstract "We characterize temporal pathway dynamics of differentiation in an in vitro neurotoxicity model with the aim of informing design and interpretation of toxicological assays. Human neural progenitor cells (hNPCs) were cultured in differentiation conditions up to 21 days. Genes significantly changed through time were identified and grouped according to temporal dynamics. Quantitative pathway analysis identified gene ontology (GO) terms enriched among significantly changed genes and provided a temporal roadmap of pathway trends in vitro. Gene expression in hNPCs was compared with publicly available gene expression data from developing human brain tissue in vivo. Quantitative pathway analysis of significantly changed genes and targeted analysis of specific pathways of interest identified concordance between in vivo and in vitro expression associated with proliferation, migration, differentiation, synapse formation, and neurotransmission. Our analysis anchors gene expression patterns in vitro to sensitive windows of in vivo development, helping to define appropriate applications of the model." @default.
- W2985242335 created "2019-11-22" @default.
- W2985242335 creator A5001722260 @default.
- W2985242335 creator A5037244087 @default.
- W2985242335 creator A5038717839 @default.
- W2985242335 creator A5047429249 @default.
- W2985242335 creator A5049906856 @default.
- W2985242335 creator A5051171682 @default.
- W2985242335 creator A5052782466 @default.
- W2985242335 creator A5059260037 @default.
- W2985242335 creator A5075503242 @default.
- W2985242335 creator A5090667749 @default.
- W2985242335 date "2020-01-01" @default.
- W2985242335 modified "2023-10-16" @default.
- W2985242335 title "Anchoring a dynamic in vitro model of human neuronal differentiation to key processes of early brain development in vivo" @default.
- W2985242335 cites W1567579472 @default.
- W2985242335 cites W1695757115 @default.
- W2985242335 cites W1952744094 @default.
- W2985242335 cites W1964285345 @default.
- W2985242335 cites W1966955323 @default.
- W2985242335 cites W1970197319 @default.
- W2985242335 cites W1970471894 @default.
- W2985242335 cites W1977374662 @default.
- W2985242335 cites W1987118807 @default.
- W2985242335 cites W1991671862 @default.
- W2985242335 cites W1996318057 @default.
- W2985242335 cites W1997584963 @default.
- W2985242335 cites W2001491328 @default.
- W2985242335 cites W2003965727 @default.
- W2985242335 cites W2004429971 @default.
- W2985242335 cites W2005205901 @default.
- W2985242335 cites W2008370035 @default.
- W2985242335 cites W2011881640 @default.
- W2985242335 cites W2018286352 @default.
- W2985242335 cites W2022689242 @default.
- W2985242335 cites W2025339663 @default.
- W2985242335 cites W2025366145 @default.
- W2985242335 cites W2027578037 @default.
- W2985242335 cites W2038875766 @default.
- W2985242335 cites W2048689329 @default.
- W2985242335 cites W2050265428 @default.
- W2985242335 cites W2066864368 @default.
- W2985242335 cites W2077776717 @default.
- W2985242335 cites W2080209696 @default.
- W2985242335 cites W2082931608 @default.
- W2985242335 cites W2086943348 @default.
- W2985242335 cites W2093150351 @default.
- W2985242335 cites W2095510160 @default.
- W2985242335 cites W2099540110 @default.
- W2985242335 cites W2106461017 @default.
- W2985242335 cites W2109101169 @default.
- W2985242335 cites W2113851821 @default.
- W2985242335 cites W2116634113 @default.
- W2985242335 cites W2119429068 @default.
- W2985242335 cites W2120095635 @default.
- W2985242335 cites W2125852172 @default.
- W2985242335 cites W2132527874 @default.
- W2985242335 cites W2133588896 @default.
- W2985242335 cites W2134941387 @default.
- W2985242335 cites W2140600830 @default.
- W2985242335 cites W2144961968 @default.
- W2985242335 cites W2145748421 @default.
- W2985242335 cites W2146512944 @default.
- W2985242335 cites W2148708580 @default.
- W2985242335 cites W2150197018 @default.
- W2985242335 cites W2152739465 @default.
- W2985242335 cites W2159884201 @default.
- W2985242335 cites W2163302580 @default.
- W2985242335 cites W2316051439 @default.
- W2985242335 cites W2507488508 @default.
- W2985242335 cites W2556547238 @default.
- W2985242335 cites W2610747598 @default.
- W2985242335 cites W2765550448 @default.
- W2985242335 cites W2779647325 @default.
- W2985242335 cites W2791245151 @default.
- W2985242335 cites W2794376805 @default.
- W2985242335 cites W2795964095 @default.
- W2985242335 cites W2799605674 @default.
- W2985242335 cites W28767225 @default.
- W2985242335 cites W336960955 @default.
- W2985242335 cites W4231659066 @default.
- W2985242335 cites W4294141750 @default.
- W2985242335 doi "https://doi.org/10.1016/j.reprotox.2019.09.005" @default.
- W2985242335 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6980388" @default.
- W2985242335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31740287" @default.
- W2985242335 hasPublicationYear "2020" @default.
- W2985242335 type Work @default.
- W2985242335 sameAs 2985242335 @default.
- W2985242335 citedByCount "1" @default.
- W2985242335 countsByYear W29852423352022 @default.
- W2985242335 crossrefType "journal-article" @default.
- W2985242335 hasAuthorship W2985242335A5001722260 @default.
- W2985242335 hasAuthorship W2985242335A5037244087 @default.
- W2985242335 hasAuthorship W2985242335A5038717839 @default.
- W2985242335 hasAuthorship W2985242335A5047429249 @default.
- W2985242335 hasAuthorship W2985242335A5049906856 @default.
- W2985242335 hasAuthorship W2985242335A5051171682 @default.
- W2985242335 hasAuthorship W2985242335A5052782466 @default.