FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985337321> ?p ?o ?g. }

• W2985337321 endingPage "172" @default.
• W2985337321 startingPage "162" @default.
• W2985337321 abstract "Progressive striatal atrophy has long been considered the pathological hallmark of Huntington's disease (HD), but is it now recognized that malfunction and degeneration of posterior-cortical territories are also prominent characteristics of the disease. The limited knowledge about the functional impact of these posterior-cortical changes could be partially attributed to the lack of sensitive measures to capture them. We hypothesized that early malfunction of specific territories of the ventral visual pathway in premanifest HD would lead to difficulties in the recognition of complex stimuli and to differences in their neurophysiological correlates. To test this idea, we used an object, face and face-like object recognition task to be conducted during an electroencephalographic recording. Compared to healthy-matched controls, premanifest participants showed a significantly increased number of recognition errors in the face-like object condition. Moreover, premanifest participants showed a dramatic decrease in the N170 component elicited for the face-like objects. This N170 decrease was significantly associated with the number of recognition errors and with severity of apathy and global cognitive performance. The lack of differences in other clinical and cognitive measures supports a selective deficit in recognition of face-like objects and their neurophysiological correlates in premanifest HD. These deficits occurred in participants up to 15 years before the estimated time to disease onset and correlated strongly with cognitive and behavioral measures known to be sensitive to HD progression. This finding highlights the existence of selective visuoperceptive deficits years before motor-based onset of HD and emphasizes the need to develop sensitive measures to capture early visual system changes in this population. Assessing the integrity of the visual cortex and its related functions in HD could help to identify early markers of disease progression." @default.
• W2985337321 created "2019-11-22" @default.
• W2985337321 creator A5014230128 @default.
• W2985337321 creator A5025217905 @default.
• W2985337321 creator A5047837851 @default.
• W2985337321 creator A5063989180 @default.
• W2985337321 creator A5067737939 @default.
• W2985337321 creator A5071683959 @default.
• W2985337321 creator A5081046376 @default.
• W2985337321 date "2020-02-01" @default.
• W2985337321 modified "2023-10-11" @default.
• W2985337321 title "Impaired face-like object recognition in premanifest Huntington's disease" @default.
• W2985337321 cites W1844862277 @default.
• W2985337321 cites W1965044870 @default.
• W2985337321 cites W1966893527 @default.
• W2985337321 cites W1968421991 @default.
• W2985337321 cites W1968668252 @default.
• W2985337321 cites W1982452856 @default.
• W2985337321 cites W1984113570 @default.
• W2985337321 cites W2000965992 @default.
• W2985337321 cites W2001689722 @default.
• W2985337321 cites W2003479599 @default.
• W2985337321 cites W2013544540 @default.
• W2985337321 cites W2014826989 @default.
• W2985337321 cites W2019778340 @default.
• W2985337321 cites W2020463965 @default.
• W2985337321 cites W2026801435 @default.
• W2985337321 cites W2032120877 @default.
• W2985337321 cites W2037420423 @default.
• W2985337321 cites W2050785417 @default.
• W2985337321 cites W2051770965 @default.
• W2985337321 cites W2055962836 @default.
• W2985337321 cites W2069535434 @default.
• W2985337321 cites W2076362842 @default.
• W2985337321 cites W2078320135 @default.
• W2985337321 cites W2082056883 @default.
• W2985337321 cites W2098958400 @default.
• W2985337321 cites W2101164117 @default.
• W2985337321 cites W2123341385 @default.
• W2985337321 cites W2124660038 @default.
• W2985337321 cites W2143895814 @default.
• W2985337321 cites W2149018929 @default.
• W2985337321 cites W2168648143 @default.
• W2985337321 cites W2169735361 @default.
• W2985337321 cites W2171441239 @default.
• W2985337321 cites W2289648442 @default.
• W2985337321 cites W2349117874 @default.
• W2985337321 cites W2405909894 @default.
• W2985337321 cites W2482651503 @default.
• W2985337321 cites W2606710341 @default.
• W2985337321 cites W2888517689 @default.
• W2985337321 cites W2898913093 @default.
• W2985337321 cites W2901251244 @default.
• W2985337321 cites W2911600415 @default.
• W2985337321 cites W2915841816 @default.
• W2985337321 cites W2935500156 @default.
• W2985337321 doi "https://doi.org/10.1016/j.cortex.2019.10.015" @default.
• W2985337321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31794910" @default.
• W2985337321 hasPublicationYear "2020" @default.
• W2985337321 type Work @default.
• W2985337321 sameAs 2985337321 @default.
• W2985337321 citedByCount "10" @default.
• W2985337321 countsByYear W29853373212020 @default.
• W2985337321 countsByYear W29853373212021 @default.
• W2985337321 countsByYear W29853373212022 @default.
• W2985337321 countsByYear W29853373212023 @default.
• W2985337321 crossrefType "journal-article" @default.
• W2985337321 hasAuthorship W2985337321A5014230128 @default.
• W2985337321 hasAuthorship W2985337321A5025217905 @default.
• W2985337321 hasAuthorship W2985337321A5047837851 @default.
• W2985337321 hasAuthorship W2985337321A5063989180 @default.
• W2985337321 hasAuthorship W2985337321A5067737939 @default.
• W2985337321 hasAuthorship W2985337321A5071683959 @default.
• W2985337321 hasAuthorship W2985337321A5081046376 @default.
• W2985337321 hasConcept C142724271 @default.
• W2985337321 hasConcept C152478114 @default.
• W2985337321 hasConcept C15744967 @default.
• W2985337321 hasConcept C169760540 @default.
• W2985337321 hasConcept C169900460 @default.
• W2985337321 hasConcept C180747234 @default.
• W2985337321 hasConcept C2776228812 @default.
• W2985337321 hasConcept C2776509080 @default.
• W2985337321 hasConcept C2779134260 @default.
• W2985337321 hasConcept C2779483572 @default.
• W2985337321 hasConcept C2780647506 @default.
• W2985337321 hasConcept C2781172350 @default.
• W2985337321 hasConcept C548259974 @default.
• W2985337321 hasConcept C71924100 @default.
• W2985337321 hasConceptScore W2985337321C142724271 @default.
• W2985337321 hasConceptScore W2985337321C152478114 @default.
• W2985337321 hasConceptScore W2985337321C15744967 @default.
• W2985337321 hasConceptScore W2985337321C169760540 @default.
• W2985337321 hasConceptScore W2985337321C169900460 @default.
• W2985337321 hasConceptScore W2985337321C180747234 @default.
• W2985337321 hasConceptScore W2985337321C2776228812 @default.
• W2985337321 hasConceptScore W2985337321C2776509080 @default.
• W2985337321 hasConceptScore W2985337321C2779134260 @default.
• W2985337321 hasConceptScore W2985337321C2779483572 @default.

• next