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• W2985462962 endingPage "154009" @default.
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• W2985462962 abstract "Metabolism affects every day life, and influences eating behaviors, energy expenditure, and daily health. Around the world, the field of metabolism is becoming increasingly critical to study as disorders and diseases related to metabolism become more prevalent. Obesity is arguably the public health problem of the century, affecting nearly 40% of United States (US) Americans [ [1] Hales C.M. Carroll M.D. Fryar C.D. Ogden C.L. Prevalence of obesity among adults and youth: United States, 2015–2016. NCHS Data Brief. 2017; : 1-8 Google Scholar ]. Cardiovascular disease (CVD), the endpoint of obesity and its comorbidities, causes >2200 deaths each day in the US, making it the leading cause of death [ [2] Mozaffarian D. Benjamin E.J. Go A.S. Arnett D.K. Blaha M.J. Cushman M. et al. Heart disease and stroke statistics—2016 update. Circulation. 2016; 133 (e38-360)https://doi.org/10.1161/CIR.0000000000000350 Crossref Scopus (3092) Google Scholar ]. Non-alcoholic fatty liver disease (NAFLD) and the more severe form of non-alcoholic steatohepatitis (NASH) are also becoming epidemics as an unmet clinical need with a prevalence for NAFLD of 30% in the general population, 40–70% in the obese and 60–90% in the diabetic population [ [3] López-Velázquez JA, Silva-Vidal K V, Ponciano-Rodríguez G, Chávez-Tapia NC, Arrese M, Uribe M, et al. The prevalence of nonalcoholic fatty liver disease in the Americas. Ann Hepatol n.d.;13:166–78. Google Scholar , [4] Targher G. Bertolini L. Padovani R. Rodella S. Tessari R. Zenari L. et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care. 2007; 30: 1212-1218https://doi.org/10.2337/dc06-2247 Crossref PubMed Scopus (596) Google Scholar ]. All of these comorbidities are associated with rising healthcare costs [ [5] Hotamisligil G.S. Inflammation and metabolic disorders. Nature. 2006; 444: 860-867https://doi.org/10.1038/nature05485 Crossref PubMed Scopus (4865) Google Scholar ]. Understanding not only the pathology, but also the physiology and mechanisms is a key goal of the field and the journal, Metabolism: Clinical and Experimental." @default.
• W2985462962 created "2019-11-22" @default.
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• W2985462962 date "2020-01-01" @default.
• W2985462962 modified "2023-09-27" @default.
• W2985462962 title "Metabolism updates: new directions, techniques, and exciting research that is broadening the horizons" @default.
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