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- W2985498068 abstract "The management of gout consists of urate-lowering therapy and acute and chronic anti-inflammatory drugs. Allopurinol, a xanthine oxidase inhibitor, is the primary urate-lowering therapy employed for decades. Recent studies suggest cardiovascular disease and mortality, chronic kidney disease, prostate cancer, and manic symptoms are reduced in patients with gout treated with allopurinol. These findings support that allopurinol contributes to a variety of beneficial effects beyond urate lowering. This manuscript reviews the analgesic and anti-inflammatory properties of allopurinol, which are rarely discussed. Several mechanisms are suggested to confer these benefits including accumulation of adenosine and inhibitory effects of allopurinol on reactive oxygen species, tumor necrosis factor- α, nuclear factor kappa-light-chain-enhancer of activated B cells, and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. Also, allopurinol blocks the stimulating effects of thioredoxin-interacting protein and interacts directly with the redox-active domain of thioredoxin as a negative regulator, decreasing NLRP3 activation. The importance of allopurinol's analgesic and anti-inflammatory properties requires further study and the implications to patient care better understood." @default.
- W2985498068 created "2019-11-22" @default.
- W2985498068 creator A5003821899 @default.
- W2985498068 creator A5079307634 @default.
- W2985498068 date "2020-06-01" @default.
- W2985498068 modified "2023-09-30" @default.
- W2985498068 title "Beyond urate lowering: Analgesic and anti-inflammatory properties of allopurinol" @default.
- W2985498068 cites W106621139 @default.
- W2985498068 cites W1514177613 @default.
- W2985498068 cites W1550147021 @default.
- W2985498068 cites W1662226698 @default.
- W2985498068 cites W1904141486 @default.
- W2985498068 cites W1964162666 @default.
- W2985498068 cites W1965130745 @default.
- W2985498068 cites W1966831973 @default.
- W2985498068 cites W1969979138 @default.
- W2985498068 cites W1970540527 @default.
- W2985498068 cites W1972947087 @default.
- W2985498068 cites W1974194847 @default.
- W2985498068 cites W1976573800 @default.
- W2985498068 cites W1976599392 @default.
- W2985498068 cites W1977110551 @default.
- W2985498068 cites W1985969855 @default.
- W2985498068 cites W1994394104 @default.
- W2985498068 cites W1996930866 @default.
- W2985498068 cites W2003196103 @default.
- W2985498068 cites W2003407110 @default.
- W2985498068 cites W2003483275 @default.
- W2985498068 cites W2003672697 @default.
- W2985498068 cites W2005641214 @default.
- W2985498068 cites W2006777365 @default.
- W2985498068 cites W2009004909 @default.
- W2985498068 cites W2010729840 @default.
- W2985498068 cites W2013734674 @default.
- W2985498068 cites W2013852456 @default.
- W2985498068 cites W2022320837 @default.
- W2985498068 cites W2023807729 @default.
- W2985498068 cites W2025059389 @default.
- W2985498068 cites W2025372788 @default.
- W2985498068 cites W2034145588 @default.
- W2985498068 cites W2036135096 @default.
- W2985498068 cites W2050928917 @default.
- W2985498068 cites W2053269045 @default.
- W2985498068 cites W2060883428 @default.
- W2985498068 cites W2063110821 @default.
- W2985498068 cites W2065273367 @default.
- W2985498068 cites W2066911756 @default.
- W2985498068 cites W2083105243 @default.
- W2985498068 cites W2084141237 @default.
- W2985498068 cites W2088291447 @default.
- W2985498068 cites W2088629626 @default.
- W2985498068 cites W2092592241 @default.
- W2985498068 cites W2094668054 @default.
- W2985498068 cites W2101391992 @default.
- W2985498068 cites W2105420327 @default.
- W2985498068 cites W2111334035 @default.
- W2985498068 cites W2116617956 @default.
- W2985498068 cites W2119515450 @default.
- W2985498068 cites W2122287804 @default.
- W2985498068 cites W2123079845 @default.
- W2985498068 cites W2127070756 @default.
- W2985498068 cites W2131101289 @default.
- W2985498068 cites W2133494322 @default.
- W2985498068 cites W2134049088 @default.
- W2985498068 cites W2135442742 @default.
- W2985498068 cites W2136764746 @default.
- W2985498068 cites W2137507465 @default.
- W2985498068 cites W2147993424 @default.
- W2985498068 cites W2153962607 @default.
- W2985498068 cites W2154947537 @default.
- W2985498068 cites W2155227685 @default.
- W2985498068 cites W2156525348 @default.
- W2985498068 cites W2158079639 @default.
- W2985498068 cites W2162376947 @default.
- W2985498068 cites W2300788339 @default.
- W2985498068 cites W23982100 @default.
- W2985498068 cites W2548080299 @default.
- W2985498068 cites W2552668956 @default.
- W2985498068 cites W2598674670 @default.
- W2985498068 cites W2606131470 @default.
- W2985498068 cites W2735446982 @default.
- W2985498068 cites W2766236640 @default.
- W2985498068 cites W2786280034 @default.
- W2985498068 cites W2883648776 @default.
- W2985498068 cites W2888741571 @default.
- W2985498068 cites W2896170318 @default.
- W2985498068 cites W2897652153 @default.
- W2985498068 cites W2916450078 @default.
- W2985498068 cites W2951036201 @default.
- W2985498068 cites W2965135765 @default.
- W2985498068 doi "https://doi.org/10.1016/j.semarthrit.2019.11.009" @default.
- W2985498068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31839209" @default.
- W2985498068 hasPublicationYear "2020" @default.
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