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• W2985556578 endingPage "350" @default.
• W2985556578 startingPage "334" @default.
• W2985556578 abstract "Abstract The ventricular layer of the spinal cord is remodelled during embryonic development and ultimately forms the ependymal cell lining of the adult central canal, which retains neural stem cell potential. This anatomical transformation involves the process of dorsal collapse; however, accompanying changes in tissue organisation and cell behaviour as well as the precise origin of cells contributing to the central canal are not well understood. Here, we describe sequential localised cell rearrangements which accompany the gradual attrition of the spinal cord ventricular layer during development. This includes local breakdown of the pseudostratified organisation of the dorsal ventricular layer prefiguring dorsal collapse and evidence for a new phenomenon, ventral dissociation, during which the ventral‐most floor plate cells separate from a subset that are retained around the central canal. Using cell proliferation markers and cell‐cycle reporter mice, we further show that following dorsal collapse, ventricular layer attrition involves an overall reduction in cell proliferation, characterised by an intriguing increase in the percentage of cells in G1/S. In contrast, programmed cell death does not contribute to ventricular layer remodelling. By analysing transcript and protein expression patterns associated with key signalling pathways, we provide evidence for a gradual decline in ventral sonic hedgehog activity and an accompanying ventral expansion of initial dorsal bone morphogenetic protein signalling, which comes to dominate the forming the central canal lining. This study identifies multiple steps that may contribute to spinal cord ventricular layer attrition and adds to increasing evidence for the heterogeneous origin of the spinal cord ependymal cell population, which includes cells from the floor plate and the roof plate as well as ventral progenitor domains." @default.
• W2985556578 created "2019-11-22" @default.
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• W2985556578 date "2019-10-31" @default.
• W2985556578 modified "2023-09-29" @default.
• W2985556578 title "Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal" @default.
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• W2985556578 doi "https://doi.org/10.1111/joa.13094" @default.
• W2985556578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6956438" @default.
• W2985556578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31670387" @default.
• W2985556578 hasPublicationYear "2019" @default.
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