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- W2985584352 abstract "Abstract There is an unmet medical need for fast-acting, effective, non-dependent and non-addicting anxiolytic treatments, in lieu of benzodiazepines. Compounded tablets of PanX® Atenolol–Scopolamine HBr were administered orally in eight patients with complex diagnoses receiving residential psychiatric care for acute anxiety and/or other conditions. Three of the eight patients were being treated for substance abuse. The primary endpoint was a reduction in the severity of State anxiety symptoms using the Beck Anxiety Instrument (BAI-S), prior to drug administration and one hour and/or approximately four hours after oral administration. Six of the eight patients were responders with a perceived calming effect and substantial reductions in their BAI-S scores. The mean of the BAI-S scores for all eight patients, including two deemed as non-responders, were 15.9 at baseline pre-treatment, 8.5 at 1 h post-treatment, and 4.1 at approximately 4 h. The mean of the heart rate was reduced from 93.6 bpm pre-treatment to 77.0 bpm at 1 h post-treatment and 79.7 bpm at 4–5 h. The mean of the blood pressure decreased by 10.1 mmHg systolic and 5.3 mmHg diastolic at 1 h post-treatment and even greater at 4–5 h. The reductions in heart rate and blood pressure are consistent with the effects of the beta blocker Atenolol. The drug combination was well tolerated in all patients with minor side effects in some, i.e., dry mouth and mild sleepiness (mild sedation). The beneficial reduction in anxiety symptoms was perceived within 15–60 min and persisted for up to 8 h." @default.
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- W2985584352 date "2020-03-01" @default.
- W2985584352 modified "2023-09-28" @default.
- W2985584352 title "Anxiolytic benefits of compounded Atenolol–Scopolamine in eight patients in psychiatry" @default.
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- W2985584352 doi "https://doi.org/10.1016/j.pmip.2019.10.001" @default.
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