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• W2985697815 endingPage "70" @default.
• W2985697815 startingPage "56" @default.
• W2985697815 abstract "<b><i>Introduction:</i></b> Phospholipases are enzymes that occur in many types of human cells, including mast cells, and play an important role in the molecular background of asthma pathogenesis, and the development of inflammation NF-κB activities that affect numerous biological processes has been reported in many inflammatory diseases including asthma. Vitamin D is a widely studied factor that affects many diseases, including asthma. The aim of this study is to assess the influence of 1,25-(OH)₂D₃ on regulation of chosen phospholipase-A2 (PLA2) expression-selected inflammation mediators. <b><i>Methods:</i></b> LUVA mast cells were stimulated with 1,25(OH)₂D₃, and inhibitors of NF-κB p65 and ubiquitination. Expression analysis of phospholipases (PLA2G5, PLA2G10, PLA2G12, PLA2G15, PLA2G4A, PLA2G4B, PLA2G4C, PLAA, NF-κB p65, and UBC) was done utilizing real-time PCR and Western blot. Eicosanoid (LTC4, LXA4, 15[S]-HETE, and PGE2) levels and sPLA₂ were also measured. <b><i>Results:</i></b> We found that 1,25(OH)₂D₃ decreased the expression of PLA2G5, PLA2G15, PLA2G5,<b><i></i></b>UBC, and NF-κB p65 but increased expression of PLAA and PLA2G4C (<i>p</i> &#x3c; 0.05). Moreover, the expression of PLA2G5 and PLA2G15 decreased after inhibition of NF-κB p65 and UBC. Increased levels of released LXA4 and 15(S)-HETE, decreased levels of LTC4, and sPLA₂s enzymatic activity in response to 1,25(OH)₂D₃ were also observed. Additionally, NF-κB p65 inhibition led to an increase in the LXA4 concentration_.<b><i>Conclusion:</i></b> Future investigations will be needed to further clarify the role of 1,25(OH)₂D₃ in the context of asthma and the inflammatory process; however, these results confirm a variety of effects which can be caused by this vitamin. 1,25(OH)₂D₃-mediated action may result in the development of new therapeutic strategies for asthma treatment." @default.
• W2985697815 created "2019-11-22" @default.
• W2985697815 creator A5034577390 @default.
• W2985697815 creator A5039000318 @default.
• W2985697815 creator A5069697575 @default.
• W2985697815 creator A5070814383 @default.
• W2985697815 date "2019-11-08" @default.
• W2985697815 modified "2023-09-30" @default.
• W2985697815 title "Wide-Range Effects of 1,25(OH)2D3 on Group 4A Phospholipases Is Related to Nuclear Factor κ-B and Phospholipase-A2 Activating Protein Activity in Mast Cells" @default.
• W2985697815 cites W1526950959 @default.
• W2985697815 cites W1530740124 @default.
• W2985697815 cites W1566973004 @default.
• W2985697815 cites W1603393469 @default.
• W2985697815 cites W1663317712 @default.
• W2985697815 cites W1780888907 @default.
• W2985697815 cites W1891008369 @default.
• W2985697815 cites W1970516100 @default.
• W2985697815 cites W1970940868 @default.
• W2985697815 cites W1971313462 @default.
• W2985697815 cites W1972664132 @default.
• W2985697815 cites W1973768662 @default.
• W2985697815 cites W1975375880 @default.
• W2985697815 cites W1977453974 @default.
• W2985697815 cites W1985817337 @default.
• W2985697815 cites W1993667889 @default.
• W2985697815 cites W1995560331 @default.
• W2985697815 cites W2000792208 @default.
• W2985697815 cites W2004774380 @default.
• W2985697815 cites W2004776159 @default.
• W2985697815 cites W2011531683 @default.
• W2985697815 cites W2013828660 @default.
• W2985697815 cites W2016582924 @default.
• W2985697815 cites W2019193747 @default.
• W2985697815 cites W2019669911 @default.
• W2985697815 cites W2027727459 @default.
• W2985697815 cites W2029564582 @default.
• W2985697815 cites W2038210107 @default.
• W2985697815 cites W2042746098 @default.
• W2985697815 cites W2043795001 @default.
• W2985697815 cites W2044696993 @default.
• W2985697815 cites W2049294966 @default.
• W2985697815 cites W2050350946 @default.
• W2985697815 cites W2058999194 @default.
• W2985697815 cites W2060757645 @default.
• W2985697815 cites W2064966602 @default.
• W2985697815 cites W2065622959 @default.
• W2985697815 cites W2068049217 @default.
• W2985697815 cites W2068514997 @default.
• W2985697815 cites W2069273020 @default.
• W2985697815 cites W2074418409 @default.
• W2985697815 cites W2075332451 @default.
• W2985697815 cites W2077677810 @default.
• W2985697815 cites W2092305488 @default.
• W2985697815 cites W2097027689 @default.
• W2985697815 cites W2103010959 @default.
• W2985697815 cites W2103592190 @default.
• W2985697815 cites W2103760204 @default.
• W2985697815 cites W2104379455 @default.
• W2985697815 cites W2106836347 @default.
• W2985697815 cites W2110564217 @default.
• W2985697815 cites W2116151144 @default.
• W2985697815 cites W2125024454 @default.
• W2985697815 cites W2136347571 @default.
• W2985697815 cites W2149109081 @default.
• W2985697815 cites W2153122867 @default.
• W2985697815 cites W2154004923 @default.
• W2985697815 cites W2162784443 @default.
• W2985697815 cites W2164273883 @default.
• W2985697815 cites W2164360357 @default.
• W2985697815 cites W2167676346 @default.
• W2985697815 cites W2170018246 @default.
• W2985697815 cites W2171077374 @default.
• W2985697815 cites W2346019307 @default.
• W2985697815 cites W2409180538 @default.
• W2985697815 cites W2482757876 @default.
• W2985697815 cites W2501093990 @default.
• W2985697815 cites W2502930770 @default.
• W2985697815 cites W2518921575 @default.
• W2985697815 cites W2529149698 @default.
• W2985697815 cites W2530977520 @default.
• W2985697815 cites W2532244501 @default.
• W2985697815 cites W2566835621 @default.
• W2985697815 cites W2579457128 @default.
• W2985697815 cites W2588906490 @default.
• W2985697815 cites W2608022923 @default.
• W2985697815 cites W2744581973 @default.
• W2985697815 cites W2752487817 @default.
• W2985697815 cites W2761444033 @default.
• W2985697815 cites W2765670639 @default.
• W2985697815 cites W2773102718 @default.
• W2985697815 cites W2788088175 @default.
• W2985697815 cites W2794129387 @default.
• W2985697815 cites W2886751961 @default.
• W2985697815 cites W2889331285 @default.
• W2985697815 cites W2902077557 @default.
• W2985697815 cites W2906506975 @default.
• W2985697815 cites W2917559279 @default.
• W2985697815 cites W2966896291 @default.

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