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- W2985716615 abstract "Metabotropic Glutamate Receptors (mGluRs) are Class C G-protein coupled receptors (GPCRs) that are expressed throughout the central nervous system and are involved in several neurological and psychiatric disorders. Although, many studies focused on Glutamate induced activation of mGluR2, however, the role of unstructured loop (or “BC loop”) in activation of metabotropic Glutamate receptors is currently unknown. Here, using Förster Resonance Energy Transfer (FRET) based assay in live cells we show that unstructured loop is required for Glutamate induced conformation and hence the activation of the receptor." @default.
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- W2985716615 date "2020-01-01" @default.
- W2985716615 modified "2023-10-14" @default.
- W2985716615 title "Unstructured loop is essential for the activation of mGluR2" @default.
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- W2985716615 doi "https://doi.org/10.1016/j.bbrc.2019.10.187" @default.
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