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- W2985733372 endingPage "3704" @default.
- W2985733372 startingPage "3704" @default.
- W2985733372 abstract "Recently, a large spectrum of biomaterials emerged, with emphasis on various pure, blended, or doped calcium phosphates (CaPs). Although basic cytocompatibility testing protocols are referred by International Organization for Standardization (ISO) 10993 (parts 1–22), rigorous in vitro testing using cutting-edge technologies should be carried out in order to fully understand the behavior of various biomaterials (whether in bulk or low-dimensional object form) and to better gauge their outcome when implanted. In this review, current molecular techniques are assessed for the in-depth characterization of angiogenic potential, osteogenic capability, and the modulation of oxidative stress and inflammation properties of CaPs and their cation- and/or anion-substituted derivatives. Using such techniques, mechanisms of action of these compounds can be deciphered, highlighting the signaling pathway activation, cross-talk, and modulation by microRNA expression, which in turn can safely pave the road toward a better filtering of the truly functional, application-ready innovative therapeutic bioceramic-based solutions." @default.
- W2985733372 created "2019-11-22" @default.
- W2985733372 creator A5013017577 @default.
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- W2985733372 creator A5084212536 @default.
- W2985733372 creator A5088264158 @default.
- W2985733372 date "2019-11-10" @default.
- W2985733372 modified "2023-10-18" @default.
- W2985733372 title "Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications" @default.
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