Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985752783> ?p ?o ?g. }
- W2985752783 endingPage "108887" @default.
- W2985752783 startingPage "108887" @default.
- W2985752783 abstract "To investigate the molecular, structural, and functional impact of aerosols from candidate modified risk tobacco products (cMRTP), the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of mainstream cigarette smoke (CS) on the cardiovascular system of ApoE-/- mice.Female ApoE-/- mice were exposed to aerosols from THS 2.2 and CHTP 1.2 or to CS from the 3R4F reference cigarette for up to 6 months at matching nicotine concentrations. A Cessation and a Switching group (3 months exposure to 3R4F CS followed by filtered air or CHTP 1.2 for 3 months) were included. Cardiovascular effects were investigated by echocardiographic, histopathological, immunohistochemical, and transcriptomics analyses.Continuous exposure to cMRTP aerosols did not affect atherosclerosis progression, heart function, left ventricular (LV) structure, or the cardiovascular transcriptome. Exposure to 3R4F CS triggered atherosclerosis progression, reduced systolic ejection fraction and fractional shortening, caused heart LV hypertrophy, and initiated significant dysregulation in the transcriptomes of the heart ventricle and thoracic aorta. Importantly, the structural, functional, and molecular changes caused by 3R4F CS were improved in the smoking cessation and switching groups.Exposure to cMRTP aerosols lacked most of the CS exposure-related functional, structural, and molecular effects. Smoking cessation or switching to CHTP 1.2 aerosol caused similar recovery from the 3R4F CS effects in the ApoE-/- model, with no further acceleration of plaque progression beyond the aging-related rate." @default.
- W2985752783 created "2019-11-22" @default.
- W2985752783 creator A5008160276 @default.
- W2985752783 creator A5012278670 @default.
- W2985752783 creator A5017568469 @default.
- W2985752783 creator A5017919384 @default.
- W2985752783 creator A5021007589 @default.
- W2985752783 creator A5021231266 @default.
- W2985752783 creator A5031579893 @default.
- W2985752783 creator A5032018257 @default.
- W2985752783 creator A5045738264 @default.
- W2985752783 creator A5047111847 @default.
- W2985752783 creator A5052080539 @default.
- W2985752783 creator A5058143169 @default.
- W2985752783 creator A5081608114 @default.
- W2985752783 creator A5087038430 @default.
- W2985752783 creator A5091278690 @default.
- W2985752783 date "2020-01-01" @default.
- W2985752783 modified "2023-09-25" @default.
- W2985752783 title "Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke" @default.
- W2985752783 cites W1559813904 @default.
- W2985752783 cites W1757785044 @default.
- W2985752783 cites W1846013564 @default.
- W2985752783 cites W1865134840 @default.
- W2985752783 cites W1966327575 @default.
- W2985752783 cites W1966742492 @default.
- W2985752783 cites W1968069972 @default.
- W2985752783 cites W1969735550 @default.
- W2985752783 cites W1978689757 @default.
- W2985752783 cites W1979041826 @default.
- W2985752783 cites W1981559442 @default.
- W2985752783 cites W1982150557 @default.
- W2985752783 cites W1983630187 @default.
- W2985752783 cites W1984627731 @default.
- W2985752783 cites W1985644650 @default.
- W2985752783 cites W1988111520 @default.
- W2985752783 cites W1988964726 @default.
- W2985752783 cites W1994227548 @default.
- W2985752783 cites W1999688162 @default.
- W2985752783 cites W2001958974 @default.
- W2985752783 cites W2004170725 @default.
- W2985752783 cites W2005185930 @default.
- W2985752783 cites W2010457001 @default.
- W2985752783 cites W2010541165 @default.
- W2985752783 cites W2013147647 @default.
- W2985752783 cites W2016769652 @default.
- W2985752783 cites W2017916813 @default.
- W2985752783 cites W2022956372 @default.
- W2985752783 cites W2029397322 @default.
- W2985752783 cites W2030559222 @default.
- W2985752783 cites W2031203524 @default.
- W2985752783 cites W2034154367 @default.
- W2985752783 cites W2034282803 @default.
- W2985752783 cites W2039639342 @default.
- W2985752783 cites W2050968841 @default.
- W2985752783 cites W2052278937 @default.
- W2985752783 cites W2056925229 @default.
- W2985752783 cites W2059447111 @default.
- W2985752783 cites W2059887272 @default.
- W2985752783 cites W2064491846 @default.
- W2985752783 cites W2065206903 @default.
- W2985752783 cites W2069051396 @default.
- W2985752783 cites W2070238605 @default.
- W2985752783 cites W2076686181 @default.
- W2985752783 cites W2081098333 @default.
- W2985752783 cites W2081969535 @default.
- W2985752783 cites W2084355267 @default.
- W2985752783 cites W2086482429 @default.
- W2985752783 cites W2086959810 @default.
- W2985752783 cites W2093263374 @default.
- W2985752783 cites W2095900642 @default.
- W2985752783 cites W2100721656 @default.
- W2985752783 cites W2103020258 @default.
- W2985752783 cites W2108090808 @default.
- W2985752783 cites W2111806742 @default.
- W2985752783 cites W2112220625 @default.
- W2985752783 cites W2113878188 @default.
- W2985752783 cites W2116634113 @default.
- W2985752783 cites W2120493345 @default.
- W2985752783 cites W2121580874 @default.
- W2985752783 cites W2124428687 @default.
- W2985752783 cites W2126172954 @default.
- W2985752783 cites W2127384758 @default.
- W2985752783 cites W2128754180 @default.
- W2985752783 cites W2131946808 @default.
- W2985752783 cites W2132279603 @default.
- W2985752783 cites W2133192860 @default.
- W2985752783 cites W2137671292 @default.
- W2985752783 cites W2141051547 @default.
- W2985752783 cites W2143218008 @default.
- W2985752783 cites W2145025818 @default.
- W2985752783 cites W2148366914 @default.
- W2985752783 cites W2148637873 @default.
- W2985752783 cites W2151197941 @default.
- W2985752783 cites W2151427388 @default.
- W2985752783 cites W2158384363 @default.
- W2985752783 cites W2158858936 @default.
- W2985752783 cites W2159474576 @default.