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- W2985764787 abstract "The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvironment of tumors. We demonstrate that glutamine blockade in tumor-bearing mice suppresses oxidative and glycolytic metabolism of cancer cells, leading to decreased hypoxia, acidosis, and nutrient depletion. By contrast, effector T cells responded to glutamine antagonism by markedly up-regulating oxidative metabolism and adopting a long-lived, highly activated phenotype. These divergent changes in cellular metabolism and programming form the basis for potent antitumor responses. Glutamine antagonism therefore exposes a previously undefined difference in metabolic plasticity between cancer cells and effector T cells that can be exploited as a metabolic checkpoint for tumor immunotherapy." @default.
- W2985764787 created "2019-11-22" @default.
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- W2985764787 date "2019-11-22" @default.
- W2985764787 modified "2023-10-09" @default.
- W2985764787 title "Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion" @default.
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- W2985764787 doi "https://doi.org/10.1126/science.aav2588" @default.
- W2985764787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7023461" @default.
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