Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985821908> ?p ?o ?g. }
- W2985821908 abstract "During spermatogenesis, up to 75% of germ cells in the testes undergo apoptosis and are cleared by Sertoli cells. X-linked XK blood group-related 8 (Xkr8) is a plasma membrane protein that scrambles phospholipids in response to apoptotic signals, exposing phosphatidylserine (PtdSer). Here, we found that Xkr8-/- male mice were infertile due to reduced sperm counts in their epididymides. Apoptotic stimuli could not induce PtdSer exposure in Xkr8-/- germ cells. Consistent with the hypothesis that PtdSer functions as an eat-me signal to phagocytes, cells expressing phosphatidylserine receptor TIM4 and MER tyrosine kinase receptor efficiently engulfed apoptotic wild-type male germ cells but not Xkr8-/- germ cells. Fluorescence and electron microscopy revealed Sertoli cells carrying engulfed and degenerated dead cells. However, many unengulfed apoptotic cells and residual bodies and much cell debris were present in Xkr8-/- testes and epididymides. These results indicate that Xkr8-mediated PtdSer exposure is essential for the clearance of apoptotic germ cells by Sertoli cells. There was no apparent inflammation in Xkr8-/- testes, suggesting that the unengulfed apoptotic cells may have undergone secondary necrosis, releasing noxious materials that affected the germ cells. Alternatively, failure to engulf the apoptotic germ cells may have caused the Sertoli cells to starve and lose their ability to support spermatogenesis." @default.
- W2985821908 created "2019-11-22" @default.
- W2985821908 creator A5018192479 @default.
- W2985821908 creator A5023624564 @default.
- W2985821908 creator A5075369226 @default.
- W2985821908 creator A5077116570 @default.
- W2985821908 date "2020-01-16" @default.
- W2985821908 modified "2023-09-30" @default.
- W2985821908 title "Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in <i>Xkr8</i>-Deficient Male Mice" @default.
- W2985821908 cites W106686820 @default.
- W2985821908 cites W1498724790 @default.
- W2985821908 cites W1560899257 @default.
- W2985821908 cites W1646925026 @default.
- W2985821908 cites W1782545213 @default.
- W2985821908 cites W1829248829 @default.
- W2985821908 cites W1969983616 @default.
- W2985821908 cites W1974646500 @default.
- W2985821908 cites W1980174384 @default.
- W2985821908 cites W1988309701 @default.
- W2985821908 cites W1991455654 @default.
- W2985821908 cites W2001758686 @default.
- W2985821908 cites W2003217505 @default.
- W2985821908 cites W2011984284 @default.
- W2985821908 cites W2019732936 @default.
- W2985821908 cites W2020841018 @default.
- W2985821908 cites W2022119516 @default.
- W2985821908 cites W2025705782 @default.
- W2985821908 cites W2027395744 @default.
- W2985821908 cites W2032758279 @default.
- W2985821908 cites W2046238955 @default.
- W2985821908 cites W2051317205 @default.
- W2985821908 cites W2051319109 @default.
- W2985821908 cites W2053084007 @default.
- W2985821908 cites W2057185316 @default.
- W2985821908 cites W2057358681 @default.
- W2985821908 cites W2058413014 @default.
- W2985821908 cites W2061227815 @default.
- W2985821908 cites W2064377209 @default.
- W2985821908 cites W2066171290 @default.
- W2985821908 cites W2074212982 @default.
- W2985821908 cites W2093565969 @default.
- W2985821908 cites W2093578282 @default.
- W2985821908 cites W2106269176 @default.
- W2985821908 cites W2113256330 @default.
- W2985821908 cites W2114206805 @default.
- W2985821908 cites W2119270102 @default.
- W2985821908 cites W2126768340 @default.
- W2985821908 cites W2126916601 @default.
- W2985821908 cites W2129723413 @default.
- W2985821908 cites W2130211930 @default.
- W2985821908 cites W2142451896 @default.
- W2985821908 cites W2145532583 @default.
- W2985821908 cites W2147402911 @default.
- W2985821908 cites W2154297032 @default.
- W2985821908 cites W2159630741 @default.
- W2985821908 cites W2163011434 @default.
- W2985821908 cites W2164229548 @default.
- W2985821908 cites W2168436056 @default.
- W2985821908 cites W2171820243 @default.
- W2985821908 cites W2191459521 @default.
- W2985821908 cites W2224482007 @default.
- W2985821908 cites W2274754252 @default.
- W2985821908 cites W2285852644 @default.
- W2985821908 cites W2286124328 @default.
- W2985821908 cites W2291071386 @default.
- W2985821908 cites W2583964565 @default.
- W2985821908 cites W2739522668 @default.
- W2985821908 cites W2785390423 @default.
- W2985821908 cites W2788640168 @default.
- W2985821908 cites W2793160733 @default.
- W2985821908 cites W2897410651 @default.
- W2985821908 cites W2921458666 @default.
- W2985821908 cites W2941354401 @default.
- W2985821908 cites W2945863457 @default.
- W2985821908 cites W2951969951 @default.
- W2985821908 cites W4200007569 @default.
- W2985821908 cites W78643927 @default.
- W2985821908 doi "https://doi.org/10.1128/mcb.00402-19" @default.
- W2985821908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6965033" @default.
- W2985821908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31712393" @default.
- W2985821908 hasPublicationYear "2020" @default.
- W2985821908 type Work @default.
- W2985821908 sameAs 2985821908 @default.
- W2985821908 citedByCount "8" @default.
- W2985821908 countsByYear W29858219082021 @default.
- W2985821908 countsByYear W29858219082022 @default.
- W2985821908 countsByYear W29858219082023 @default.
- W2985821908 crossrefType "journal-article" @default.
- W2985821908 hasAuthorship W2985821908A5018192479 @default.
- W2985821908 hasAuthorship W2985821908A5023624564 @default.
- W2985821908 hasAuthorship W2985821908A5075369226 @default.
- W2985821908 hasAuthorship W2985821908A5077116570 @default.
- W2985821908 hasBestOaLocation W29858219082 @default.
- W2985821908 hasConcept C104317684 @default.
- W2985821908 hasConcept C123765429 @default.
- W2985821908 hasConcept C134018914 @default.
- W2985821908 hasConcept C16685009 @default.
- W2985821908 hasConcept C190283241 @default.
- W2985821908 hasConcept C2778918659 @default.
- W2985821908 hasConcept C2779122487 @default.