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• W2985908874 abstract "The use of stable isotopic labelled glucose enables insight into glucose metabolism. The C isotopic enrichment of glucose is usually analysed by gas chromatography mass spectrometry (GC/MS) or gas chromatography combustion isotope ratio mass spectrometry (GC/IRMS). However, in both techniques the samples must be derivatized prior to analysis, which makes sample preparation more labour intensive and increases the uncertainty on the measured isotopic composition. A novel method for the determination of isotopic enrichment of glucose in human plasma is using liquid chromatography isotope ratio mass spectrometry (LC/IRMS) has been developed. Using this technique, for which hardly any sample preparation is needed, we showed that both the enrichment and concentration could be measured with very high precision using only 20 μL of plasma. C h ap te r 2 In addition, a comparison with GC/MS and GC/IRMS showed best performances were achieved with the LC/IRMS method making it the method of choice to measure C isotopic enrichment in plasma samples." @default.
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• W2985908874 date "2009-01-01" @default.
• W2985908874 modified "2023-09-27" @default.
• W2985908874 title "You Are What You Eat" @default.
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