FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2985958213> ?p ?o ?g. }

• W2985958213 endingPage "36373" @default.
• W2985958213 startingPage "36366" @default.
• W2985958213 abstract "The hematopoietic system is highly sensitive to ionizing radiation (IR), and IR can cause injury to hematopoietic stem cells (HSCs); the main reason for this may be elevated reactive oxygen species (ROS) levels. Propofol is an anesthetic drug commonly used in clinical practice. The chemical structure of propofol is similar to that of vitamin E, and propofol has an antioxidant capacity. Therefore, in this work the effect of using propofol to protect against IR-induced hematopoietic system injury is evaluated. The data suggested that when the irradiated mice were treated with 20 mg kg-1 of propofol, the survival rate of lethally irradiated mice increased significantly, furthermore, the radiation-induced decrease of white blood cells (WBCs), red blood cells (RBCs), hemoglobin (HGC) and platelets (PLT) in peripheral blood is improved significantly. In addition, propofol could also increase the irradiated HSC and hematopoietic progenitor cell (HPC) frequencies, improving the self-renewal and differentiation abilities of HSCs and HPCs in irradiated mice. Next the ROS levels in HSCs and HPCs were measured, and the results showed that propofol could effectively decrease the ROS levels in these cells. The underlying ROS-scavenging mechanisms are further explored, and the results show that the Nrf2 pathway plays an important role in propofol's radiation protective effects, however, propofol can also increase the proliferation of the Nrf2 inhibitor-treated Lineage- cells after exposure to 4 Gy radiation. The data suggest that propofol has a radio-protective effect against IR-induced hematopoietic system damage through reducing cellular ROS in HSCs and HPCs partly through the Nrf2 pathway." @default.
• W2985958213 created "2019-11-22" @default.
• W2985958213 creator A5019657990 @default.
• W2985958213 creator A5029881551 @default.
• W2985958213 creator A5031305342 @default.
• W2985958213 creator A5039918498 @default.
• W2985958213 creator A5047746939 @default.
• W2985958213 creator A5069323001 @default.
• W2985958213 creator A5086699614 @default.
• W2985958213 date "2019-01-01" @default.
• W2985958213 modified "2023-09-23" @default.
• W2985958213 title "The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice" @default.
• W2985958213 cites W1526883212 @default.
• W2985958213 cites W1991402389 @default.
• W2985958213 cites W1999944210 @default.
• W2985958213 cites W2037570680 @default.
• W2985958213 cites W2051646620 @default.
• W2985958213 cites W2057485681 @default.
• W2985958213 cites W2072703637 @default.
• W2985958213 cites W2077560838 @default.
• W2985958213 cites W2096981089 @default.
• W2985958213 cites W2117460132 @default.
• W2985958213 cites W2117800935 @default.
• W2985958213 cites W2262094736 @default.
• W2985958213 cites W2290466312 @default.
• W2985958213 cites W2552409792 @default.
• W2985958213 cites W2566317874 @default.
• W2985958213 cites W2567665151 @default.
• W2985958213 cites W2581034246 @default.
• W2985958213 cites W2581680767 @default.
• W2985958213 cites W2605130959 @default.
• W2985958213 cites W2610926560 @default.
• W2985958213 cites W2620063430 @default.
• W2985958213 cites W2770364174 @default.
• W2985958213 cites W2888863350 @default.
• W2985958213 cites W2889385631 @default.
• W2985958213 cites W2892250154 @default.
• W2985958213 cites W4236445721 @default.
• W2985958213 cites W954271426 @default.
• W2985958213 doi "https://doi.org/10.1039/c9ra07262d" @default.
• W2985958213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35540614" @default.
• W2985958213 hasPublicationYear "2019" @default.
• W2985958213 type Work @default.
• W2985958213 sameAs 2985958213 @default.
• W2985958213 citedByCount "1" @default.
• W2985958213 countsByYear W29859582132021 @default.
• W2985958213 crossrefType "journal-article" @default.
• W2985958213 hasAuthorship W2985958213A5019657990 @default.
• W2985958213 hasAuthorship W2985958213A5029881551 @default.
• W2985958213 hasAuthorship W2985958213A5031305342 @default.
• W2985958213 hasAuthorship W2985958213A5039918498 @default.
• W2985958213 hasAuthorship W2985958213A5047746939 @default.
• W2985958213 hasAuthorship W2985958213A5069323001 @default.
• W2985958213 hasAuthorship W2985958213A5086699614 @default.
• W2985958213 hasBestOaLocation W29859582131 @default.
• W2985958213 hasConcept C109159458 @default.
• W2985958213 hasConcept C111337013 @default.
• W2985958213 hasConcept C121332964 @default.
• W2985958213 hasConcept C18231593 @default.
• W2985958213 hasConcept C185544564 @default.
• W2985958213 hasConcept C185592680 @default.
• W2985958213 hasConcept C203014093 @default.
• W2985958213 hasConcept C2776277131 @default.
• W2985958213 hasConcept C2778004101 @default.
• W2985958213 hasConcept C28328180 @default.
• W2985958213 hasConcept C48349386 @default.
• W2985958213 hasConcept C55493867 @default.
• W2985958213 hasConcept C86803240 @default.
• W2985958213 hasConcept C95444343 @default.
• W2985958213 hasConcept C98274493 @default.
• W2985958213 hasConceptScore W2985958213C109159458 @default.
• W2985958213 hasConceptScore W2985958213C111337013 @default.
• W2985958213 hasConceptScore W2985958213C121332964 @default.
• W2985958213 hasConceptScore W2985958213C18231593 @default.
• W2985958213 hasConceptScore W2985958213C185544564 @default.
• W2985958213 hasConceptScore W2985958213C185592680 @default.
• W2985958213 hasConceptScore W2985958213C203014093 @default.
• W2985958213 hasConceptScore W2985958213C2776277131 @default.
• W2985958213 hasConceptScore W2985958213C2778004101 @default.
• W2985958213 hasConceptScore W2985958213C28328180 @default.
• W2985958213 hasConceptScore W2985958213C48349386 @default.
• W2985958213 hasConceptScore W2985958213C55493867 @default.
• W2985958213 hasConceptScore W2985958213C86803240 @default.
• W2985958213 hasConceptScore W2985958213C95444343 @default.
• W2985958213 hasConceptScore W2985958213C98274493 @default.
• W2985958213 hasIssue "62" @default.
• W2985958213 hasLocation W29859582131 @default.
• W2985958213 hasLocation W29859582132 @default.
• W2985958213 hasLocation W29859582133 @default.
• W2985958213 hasOpenAccess W2985958213 @default.
• W2985958213 hasPrimaryLocation W29859582131 @default.
• W2985958213 hasRelatedWork W1975268103 @default.
• W2985958213 hasRelatedWork W1996916774 @default.
• W2985958213 hasRelatedWork W2033885445 @default.
• W2985958213 hasRelatedWork W2058537378 @default.
• W2985958213 hasRelatedWork W2099977590 @default.
• W2985958213 hasRelatedWork W2120223845 @default.
• W2985958213 hasRelatedWork W2121709505 @default.

• next