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• W2985993095 endingPage "132" @default.
• W2985993095 startingPage "121" @default.
• W2985993095 abstract "Thermosensitive transient receptor potential vanilloid (TRPV) channels are widely expressed in the brain and known to profoundly influence Ca2+-signaling, neurotransmitter release and behavior. While these channels are expressed in the cerebellum, neuronal firing and hyperactivity/reflexes seem associated with cerebellar temperature modulation. However, the distribution and functional significance of TRPV-equipped elements in the cerebellum has remained unexplored. Among TRPV sub-family, TRPV3 is regulated by temperature within physiological range and its transcript highly expressed in the brain. The study aims at exploring the relevance of TRPV3 in the cerebellum of developing and adult rat. RT-PCR analysis showed expression of N- and C-terminal fragments of TRPV3 mRNA in the adult rat cerebellum. Using double immunofluorescence, TRPV3-immunoreactivity was observed in Calbindin D28K-labeled Purkinje neurons. The sections of cerebellum from the postnatal rats (P4, P8, P16 and P42) were processed for TRPV3-immunofluorescence. Compared to P4 and P8, the percent fluorescent area of TRPV3-immunoreactivity significantly increased in the cerebellum of P16 and P42 rats. With a view to test the significance of TRPV3 in cerebellar function, TRPV3-agonist (eugenol) or -inhibitors [ruthenium red or isopentenyl pyrophosphate (IPP)] were administered stereotaxically intra-cerebellum and motor responses analyzed. Compared to controls, rats injected with TRPV3 inhibitor significantly reduced the stride length (P < 0.001), locomotor activity (P < 0.001), and rotarod retention time (P < 0.001), but increased footprints length (P < 0.01) and escape latency (P < 0001). TRPV3-agonist treatment, however, had no effect on these behaviors. We suggest that TRPV3 in Purkinje neurons may serve as novel molecular component for Ca2+-signaling and motor coordination function of the cerebellum." @default.
• W2985993095 created "2019-11-22" @default.
• W2985993095 creator A5009142848 @default.
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• W2985993095 creator A5061775333 @default.
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• W2985993095 creator A5085860724 @default.
• W2985993095 date "2020-01-01" @default.
• W2985993095 modified "2023-10-17" @default.
• W2985993095 title "Transient Receptor Potential Vanilloid 3 (TRPV3) in the Cerebellum of Rat and Its Role in Motor Coordination" @default.
• W2985993095 cites W1499317796 @default.
• W2985993095 cites W1527538628 @default.
• W2985993095 cites W1537888364 @default.
• W2985993095 cites W1547335662 @default.
• W2985993095 cites W1567917794 @default.
• W2985993095 cites W1582286758 @default.
• W2985993095 cites W1586627518 @default.
• W2985993095 cites W1746647265 @default.
• W2985993095 cites W1747456758 @default.
• W2985993095 cites W1839710879 @default.
• W2985993095 cites W1955716838 @default.
• W2985993095 cites W1965425684 @default.
• W2985993095 cites W1966176614 @default.
• W2985993095 cites W1966809675 @default.
• W2985993095 cites W1970263992 @default.
• W2985993095 cites W1971467783 @default.
• W2985993095 cites W1973736177 @default.
• W2985993095 cites W1974214628 @default.
• W2985993095 cites W1974585341 @default.
• W2985993095 cites W1980315648 @default.
• W2985993095 cites W1984394199 @default.
• W2985993095 cites W1989444021 @default.
• W2985993095 cites W1990251108 @default.
• W2985993095 cites W1992391707 @default.
• W2985993095 cites W1992451319 @default.
• W2985993095 cites W1993481663 @default.
• W2985993095 cites W2001887704 @default.
• W2985993095 cites W2003510700 @default.
• W2985993095 cites W2003945052 @default.
• W2985993095 cites W2005312899 @default.
• W2985993095 cites W2006549675 @default.
• W2985993095 cites W2011162934 @default.
• W2985993095 cites W2017047663 @default.
• W2985993095 cites W2018021139 @default.
• W2985993095 cites W2019293440 @default.
• W2985993095 cites W2021158045 @default.
• W2985993095 cites W2021789384 @default.
• W2985993095 cites W2023036324 @default.
• W2985993095 cites W2023578856 @default.
• W2985993095 cites W2026129983 @default.
• W2985993095 cites W2032785957 @default.
• W2985993095 cites W2033629976 @default.
• W2985993095 cites W2033906035 @default.
• W2985993095 cites W2040664792 @default.
• W2985993095 cites W2041613236 @default.
• W2985993095 cites W2043661152 @default.
• W2985993095 cites W2045713348 @default.
• W2985993095 cites W2048986387 @default.
• W2985993095 cites W2053290727 @default.
• W2985993095 cites W2053950140 @default.
• W2985993095 cites W2055004729 @default.
• W2985993095 cites W2055025881 @default.
• W2985993095 cites W2056065242 @default.
• W2985993095 cites W2056268328 @default.
• W2985993095 cites W2063571324 @default.
• W2985993095 cites W2065128164 @default.
• W2985993095 cites W2074411049 @default.
• W2985993095 cites W2083802751 @default.
• W2985993095 cites W2087329385 @default.
• W2985993095 cites W2088158546 @default.
• W2985993095 cites W2090706811 @default.
• W2985993095 cites W2090858933 @default.
• W2985993095 cites W2091589506 @default.
• W2985993095 cites W2094955398 @default.
• W2985993095 cites W2096773815 @default.
• W2985993095 cites W2100241249 @default.
• W2985993095 cites W2106698966 @default.
• W2985993095 cites W2115607358 @default.
• W2985993095 cites W2117006280 @default.
• W2985993095 cites W2124741719 @default.
• W2985993095 cites W2124873219 @default.
• W2985993095 cites W2127012396 @default.
• W2985993095 cites W2131701468 @default.
• W2985993095 cites W2134550272 @default.
• W2985993095 cites W2137261393 @default.
• W2985993095 cites W2145216076 @default.
• W2985993095 cites W2154063162 @default.
• W2985993095 cites W2164216729 @default.
• W2985993095 cites W2169473035 @default.
• W2985993095 cites W2178459653 @default.
• W2985993095 cites W2272622027 @default.
• W2985993095 cites W2283930035 @default.
• W2985993095 cites W2305984414 @default.
• W2985993095 cites W2339929595 @default.
• W2985993095 cites W2562762563 @default.
• W2985993095 cites W2590860127 @default.

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