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• W2985996895 endingPage "110966" @default.
• W2985996895 startingPage "110966" @default.
• W2985996895 abstract "Key issues around the evaluation of risks to humans from mineral oils in food and feedstuffs are discussed. MOHs (MOAH and MOSH) occur in food due to intentional use, contamination from environmental sources and during transport/processing, or through migration from food contact materials. Problems in setting and enforcing human health guidelines for MOH include uncertainty around MOH toxicity and the specialist expertise needed for analysis of complex food matrices. Currently, the method of choice for measuring mineral oils is LC-GC-FID, however some complex food matrices also require additional analytical techniques to differentiate between some naturally occurring hydrocarbons and those from other sources, including of petrogenic origin. This requires the skills of an experienced analyst. Significant toxicological gaps for MOHs prevent robust human health risk assessment and the derivation of guidance values. As food-grade mineral oils are virtually MOAH-free, the key issue explored here is the relevance to humans of liver (micro)granulomas observed in F344 rats following oral intake. Available data suggest that despite the ubiquitous nature of MOH in the human diet, the prevalence of liver lipogranulomas in the population is low. These are not associated with inflammation and based on current evidence are not considered of human health significance." @default.
• W2985996895 created "2019-11-22" @default.
• W2985996895 creator A5006904799 @default.
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• W2985996895 creator A5053246487 @default.
• W2985996895 date "2020-02-01" @default.
• W2985996895 modified "2023-10-03" @default.
• W2985996895 title "Evaluating the risk to humans from mineral oils in foods: Current state of the evidence" @default.
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• W2985996895 doi "https://doi.org/10.1016/j.fct.2019.110966" @default.
• W2985996895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31751646" @default.
• W2985996895 hasPublicationYear "2020" @default.
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