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- W2986112240 abstract "To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondro- genic differentiation without promoting terminal differ- entiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 system and identified oxytetracycline (Oxy) as a chon- drogenic compound. Oxy induced cartilaginous matrix synthesis and mRNA expressions of chondrocyte markers in ATDC5 cells. In addition, Oxy suppressed minerali- zation and mRNA expressions of terminal chondrocyte differentiation markers in ATDC5 cells, primary chondrocytes, and cultured metatarsal bones. Oxy's induction of Col2 mRNA expression was decreased by the addition of Noggin and was increased by the addition of BMP2. Furthermore, Oxy increased mRNA expression of Id1, Bmp2, Bmp4, and Bmp6. These data suggest that Oxy induces chondrogenic differentiation in a BMP- dependent manner and suppresses terminal differentiation. Oxy may be useful for treatment of OA and also for regeneration of cartilage tissue." @default.
- W2986112240 created "2019-11-22" @default.
- W2986112240 creator A5028697738 @default.
- W2986112240 date "2010-01-01" @default.
- W2986112240 modified "2023-09-27" @default.
- W2986112240 title "Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system" @default.
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