FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986144435> ?p ?o ?g. }

• W2986144435 endingPage "14" @default.
• W2986144435 startingPage "1" @default.
• W2986144435 abstract "Specialized proresolving mediators (SPRM), which arise from n-3 long-chain polyunsaturated fatty acids (n-3FA), promote resolution of inflammation and may help to prevent progression of an acute inflammatory response into chronic inflammation in patients with arthritis. Thus, this study is aimed at determining whether systemic RvE1 treatment reduces arthritis onset and severity in murine collagen-induced arthritis (CIA) and spontaneous cytokine production by human rheumatoid arthritis (RA) synovial explants. 10-week-old DBA1/J male mice were subjected to CIA and treated systemically with 0.1 μ g RvE1, 1 μ g RvE1, 5 mg/kg anti-TNF (positive control group), PBS (negative control group), or with a combination of 1 μ g of RvE1 plus 5 mg/kg anti-TNF using prophylactic or therapeutic strategies. After CIA immunization, mice were treated twice a week by RvE1 or anti-TNF for 10 days. Arthritis development was assessed by visual scoring of paw swelling and histology of ankle joints. Moreover, human RA synovial explants were incubated with 1 nM, 10 nM, or 100 nM of RvE1, and cytokine levels (IL-1 β , IL-6, IL-8, IL-10, INF- γ , and TNF- α ) were measured using Luminex bead array. CIA triggered significant inflammation in the synovial cavity, proteoglycan loss, and cartilage and bone destruction in the ankle joints of mice. Prophylactic and therapeutic RvE1 regimens did not ameliorate CIA incidence and severity. Anti-TNF treatment significantly abrogated signs of joint inflammation, bone erosion, and proteoglycan depletion, but additional RvE1 treatment did not further reduce the anti-TNF-mediated suppression of the disease. Treatment with different concentrations of RvE1 did not decrease the expression of proinflammatory cytokines in human RA synovial explants in the studied conditions. Collectively, our findings demonstrated that RvE1 treatment was not an effective approach to treat CIA in DBA1/J mice in both prophylactic and therapeutic strategies. Furthermore, no effects were noticed when human synovial explants were incubated with different concentrations of RvE1." @default.
• W2986144435 created "2019-11-22" @default.
• W2986144435 creator A5020368726 @default.
• W2986144435 creator A5023004311 @default.
• W2986144435 creator A5026099590 @default.
• W2986144435 creator A5033347806 @default.
• W2986144435 creator A5078871756 @default.
• W2986144435 creator A5082114687 @default.
• W2986144435 creator A5090930450 @default.
• W2986144435 date "2019-10-31" @default.
• W2986144435 modified "2023-10-14" @default.
• W2986144435 title "Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study" @default.
• W2986144435 cites W1657484783 @default.
• W2986144435 cites W1966247104 @default.
• W2986144435 cites W1969559624 @default.
• W2986144435 cites W1976173807 @default.
• W2986144435 cites W2033228977 @default.
• W2986144435 cites W2045144594 @default.
• W2986144435 cites W2051793746 @default.
• W2986144435 cites W2062701897 @default.
• W2986144435 cites W2064990609 @default.
• W2986144435 cites W2067637071 @default.
• W2986144435 cites W2069508760 @default.
• W2986144435 cites W2074438676 @default.
• W2986144435 cites W2075365278 @default.
• W2986144435 cites W2079790969 @default.
• W2986144435 cites W2084030755 @default.
• W2986144435 cites W2089367999 @default.
• W2986144435 cites W2090609282 @default.
• W2986144435 cites W2096652486 @default.
• W2986144435 cites W2096827857 @default.
• W2986144435 cites W2099005050 @default.
• W2986144435 cites W2103010344 @default.
• W2986144435 cites W2104823342 @default.
• W2986144435 cites W2114633137 @default.
• W2986144435 cites W2119338383 @default.
• W2986144435 cites W2119716615 @default.
• W2986144435 cites W2121190453 @default.
• W2986144435 cites W2132487687 @default.
• W2986144435 cites W2151701775 @default.
• W2986144435 cites W2154748957 @default.
• W2986144435 cites W2155590518 @default.
• W2986144435 cites W2158718496 @default.
• W2986144435 cites W2163464181 @default.
• W2986144435 cites W2164517246 @default.
• W2986144435 cites W2165433466 @default.
• W2986144435 cites W2166317809 @default.
• W2986144435 cites W2203493788 @default.
• W2986144435 cites W2293276114 @default.
• W2986144435 cites W2293416144 @default.
• W2986144435 cites W2322802533 @default.
• W2986144435 cites W2507401895 @default.
• W2986144435 cites W2552234711 @default.
• W2986144435 cites W2585594141 @default.
• W2986144435 cites W2589710212 @default.
• W2986144435 cites W2634993714 @default.
• W2986144435 cites W2751736205 @default.
• W2986144435 cites W2794762990 @default.
• W2986144435 cites W2808018118 @default.
• W2986144435 cites W2972751862 @default.
• W2986144435 cites W4210968471 @default.
• W2986144435 cites W4322703114 @default.
• W2986144435 cites W75854533 @default.
• W2986144435 doi "https://doi.org/10.1155/2019/5689465" @default.
• W2986144435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6875002" @default.
• W2986144435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31780864" @default.
• W2986144435 hasPublicationYear "2019" @default.
• W2986144435 type Work @default.
• W2986144435 sameAs 2986144435 @default.
• W2986144435 citedByCount "10" @default.
• W2986144435 countsByYear W29861444352020 @default.
• W2986144435 countsByYear W29861444352021 @default.
• W2986144435 countsByYear W29861444352022 @default.
• W2986144435 countsByYear W29861444352023 @default.
• W2986144435 crossrefType "journal-article" @default.
• W2986144435 hasAuthorship W2986144435A5020368726 @default.
• W2986144435 hasAuthorship W2986144435A5023004311 @default.
• W2986144435 hasAuthorship W2986144435A5026099590 @default.
• W2986144435 hasAuthorship W2986144435A5033347806 @default.
• W2986144435 hasAuthorship W2986144435A5078871756 @default.
• W2986144435 hasAuthorship W2986144435A5082114687 @default.
• W2986144435 hasAuthorship W2986144435A5090930450 @default.
• W2986144435 hasBestOaLocation W29861444351 @default.
• W2986144435 hasConcept C126322002 @default.
• W2986144435 hasConcept C142724271 @default.
• W2986144435 hasConcept C17991360 @default.
• W2986144435 hasConcept C203014093 @default.
• W2986144435 hasConcept C204787440 @default.
• W2986144435 hasConcept C2776164576 @default.
• W2986144435 hasConcept C2776268809 @default.
• W2986144435 hasConcept C2776914184 @default.
• W2986144435 hasConcept C2777077863 @default.
• W2986144435 hasConcept C2777226972 @default.
• W2986144435 hasConcept C2777575956 @default.
• W2986144435 hasConcept C2778690821 @default.
• W2986144435 hasConcept C2779244835 @default.
• W2986144435 hasConcept C71924100 @default.
• W2986144435 hasConcept C90924648 @default.

• next