Matches in SemOpenAlex for { <https://semopenalex.org/work/W2986182493> ?p ?o ?g. }
- W2986182493 endingPage "2515" @default.
- W2986182493 startingPage "2487" @default.
- W2986182493 abstract "Abstract The hypothalamo–pituitary–adrenal (HPA) axis plays a key role in the neuroendocrine response to stress and in maintaining physiological homoeostasis. However, stress that is chronic in nature can lead to HPA axis dysfunction and increase the risk for developing affective disorders, particularly if the stress is experienced during vulnerable periods in life. Sex differences in how the HPA axis responds to stress are well established, with females typically displaying heightened responses. The underlying cause of these sex differences is important to understand, as many neuropsychiatric disorders disproportionately affect females. Much research has provided evidence for gonadal sex steroids in underpinning sex differences in HPA axis responsivity; however, we suggest that neuroactive metabolites of these steroids also play a key role in the brain in mediating sex differences in HPA axis responses to stress. The relationship between neuroactive steroids and stress is complex. Acute stress rapidly increases neuroactive steroid production, which can in turn modulate activity of the HPA axis. However, under chronic stress conditions, stress can impact the brain's capacity to generate steroids, and this in turn has corollary effects on HPA axis function that may increase the propensity for psychopathology, given both HPA axis dysfunction and deficits in neuroactive steroids are implicated in affective disorders. Hence, here we review the evidence from animal and human studies for sex differences in the interactions between neuroactive steroids and the stress axis at various stages of life, under physiological and pathophysiological stress conditions and consider the implications for health and disease." @default.
- W2986182493 created "2019-11-22" @default.
- W2986182493 creator A5032207057 @default.
- W2986182493 creator A5077217228 @default.
- W2986182493 date "2019-12-16" @default.
- W2986182493 modified "2023-10-05" @default.
- W2986182493 title "Sex, stress and steroids" @default.
- W2986182493 cites W1140196183 @default.
- W2986182493 cites W124461014 @default.
- W2986182493 cites W1485312263 @default.
- W2986182493 cites W1492699395 @default.
- W2986182493 cites W1523733505 @default.
- W2986182493 cites W1533609384 @default.
- W2986182493 cites W1535894955 @default.
- W2986182493 cites W1540526472 @default.
- W2986182493 cites W1548863913 @default.
- W2986182493 cites W1558137567 @default.
- W2986182493 cites W1573410599 @default.
- W2986182493 cites W1588280270 @default.
- W2986182493 cites W1589321720 @default.
- W2986182493 cites W1595141823 @default.
- W2986182493 cites W1638492000 @default.
- W2986182493 cites W1678261667 @default.
- W2986182493 cites W1756324357 @default.
- W2986182493 cites W1825208184 @default.
- W2986182493 cites W1856629182 @default.
- W2986182493 cites W1912022866 @default.
- W2986182493 cites W1916395565 @default.
- W2986182493 cites W1917336488 @default.
- W2986182493 cites W1939000027 @default.
- W2986182493 cites W1949928978 @default.
- W2986182493 cites W1954064623 @default.
- W2986182493 cites W1963959378 @default.
- W2986182493 cites W1964544239 @default.
- W2986182493 cites W1964798550 @default.
- W2986182493 cites W1965486589 @default.
- W2986182493 cites W1969909017 @default.
- W2986182493 cites W1970590111 @default.
- W2986182493 cites W1972322147 @default.
- W2986182493 cites W1972732038 @default.
- W2986182493 cites W1973518997 @default.
- W2986182493 cites W1973950070 @default.
- W2986182493 cites W1974800864 @default.
- W2986182493 cites W1975252975 @default.
- W2986182493 cites W1977556590 @default.
- W2986182493 cites W1978823883 @default.
- W2986182493 cites W1980099277 @default.
- W2986182493 cites W1981496403 @default.
- W2986182493 cites W1982226361 @default.
- W2986182493 cites W1983235901 @default.
- W2986182493 cites W1983242089 @default.
- W2986182493 cites W1984508430 @default.
- W2986182493 cites W1986062308 @default.
- W2986182493 cites W1987253310 @default.
- W2986182493 cites W1987263856 @default.
- W2986182493 cites W1987266621 @default.
- W2986182493 cites W1989257227 @default.
- W2986182493 cites W1989398852 @default.
- W2986182493 cites W1990367576 @default.
- W2986182493 cites W1990623083 @default.
- W2986182493 cites W1991410461 @default.
- W2986182493 cites W1991780644 @default.
- W2986182493 cites W1992396112 @default.
- W2986182493 cites W1992874462 @default.
- W2986182493 cites W1992879638 @default.
- W2986182493 cites W1993159694 @default.
- W2986182493 cites W1993904321 @default.
- W2986182493 cites W1994075850 @default.
- W2986182493 cites W1994143964 @default.
- W2986182493 cites W1994345705 @default.
- W2986182493 cites W1994740828 @default.
- W2986182493 cites W1996011857 @default.
- W2986182493 cites W1999156531 @default.
- W2986182493 cites W2000219660 @default.
- W2986182493 cites W2000712333 @default.
- W2986182493 cites W2000976679 @default.
- W2986182493 cites W2001017562 @default.
- W2986182493 cites W2001131875 @default.
- W2986182493 cites W2001396193 @default.
- W2986182493 cites W2002862204 @default.
- W2986182493 cites W2003656057 @default.
- W2986182493 cites W2004052823 @default.
- W2986182493 cites W2004428408 @default.
- W2986182493 cites W2005595350 @default.
- W2986182493 cites W2006173908 @default.
- W2986182493 cites W2006578440 @default.
- W2986182493 cites W2007277582 @default.
- W2986182493 cites W2007636259 @default.
- W2986182493 cites W2008994881 @default.
- W2986182493 cites W2009447217 @default.
- W2986182493 cites W2009577163 @default.
- W2986182493 cites W2009742344 @default.
- W2986182493 cites W2011305202 @default.
- W2986182493 cites W2014443002 @default.
- W2986182493 cites W2014570372 @default.
- W2986182493 cites W2015330206 @default.
- W2986182493 cites W2015374221 @default.
- W2986182493 cites W2015793781 @default.